(2S,4R)-4-[[[[2-[[叔丁氧羰基]氨基]乙基]氨基]羰基]氧基]-1,2-吡咯烷二甲酸 1-(9H-芴-9-基甲基)酯合成路线 （共 7 条）
反应条件
triethylamine in water; acetonitrile T=40°C; 2.5 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2004/52817 A1, 2004 ;
Location in patent: Page 19-20 ;
反应条件
1: Fmoc-(2S,4R)-(4-OCO-NH-CH2-CH2-NH-Boc)-Pro-OMe With sodium hydroxide in 1,4-dioxane 2: 1-[[(9H-fluoren-9-ylmethoxy)carbonyl]oxy]-2,5-pyrrolidinedione With sodium carbonate in tetrahydrofuran T=20°C; 18 h;
参考文献
Lewis, Ian; Bauer, Wilfried; Albert, Rainer; Chandramouli, Nagarajan; Pless, Janos; Weckbecker, Gisbert; Bruns, Christian
Journal of Medicinal Chemistry, 2003 , vol. 46, # 12 p. 2334 - 2344
反应条件
1.1: 85 percent / aq. sodium carbonate / tetrahydrofuran / 18 h / 20 °C 2.1: tetrahydrofuran / 3 h / 20 °C 3.1: 51.0 g / (dimethylamino)pyridine / tetrahydrofuran / 20 °C 4.1: aq. NaOH / dioxane 4.2: 71 percent / aq. sodium carbonate / tetrahydrofuran / 18 h / 20 °C View Scheme
参考文献
Lewis, Ian; Bauer, Wilfried; Albert, Rainer; Chandramouli, Nagarajan; Pless, Janos; Weckbecker, Gisbert; Bruns, Christian
Journal of Medicinal Chemistry, 2003 , vol. 46, # 12 p. 2334 - 2344
反应条件
1.1: 85 percent / aq. sodium carbonate / tetrahydrofuran / 18 h / 20 °C 2.1: tetrahydrofuran / 3 h / 20 °C 3.1: 51.0 g / (dimethylamino)pyridine / tetrahydrofuran / 20 °C 4.1: aq. NaOH / dioxane 4.2: 71 percent / aq. sodium carbonate / tetrahydrofuran / 18 h / 20 °C View Scheme
参考文献
Lewis, Ian; Bauer, Wilfried; Albert, Rainer; Chandramouli, Nagarajan; Pless, Janos; Weckbecker, Gisbert; Bruns, Christian
Journal of Medicinal Chemistry, 2003 , vol. 46, # 12 p. 2334 - 2344
反应条件
1.1: tetrahydrofuran / 3 h / 20 °C 2.1: 51.0 g / (dimethylamino)pyridine / tetrahydrofuran / 20 °C 3.1: aq. NaOH / dioxane 3.2: 71 percent / aq. sodium carbonate / tetrahydrofuran / 18 h / 20 °C View Scheme
参考文献
Lewis, Ian; Bauer, Wilfried; Albert, Rainer; Chandramouli, Nagarajan; Pless, Janos; Weckbecker, Gisbert; Bruns, Christian
Journal of Medicinal Chemistry, 2003 , vol. 46, # 12 p. 2334 - 2344
反应条件
1.1: 51.0 g / (dimethylamino)pyridine / tetrahydrofuran / 20 °C 2.1: aq. NaOH / dioxane 2.2: 71 percent / aq. sodium carbonate / tetrahydrofuran / 18 h / 20 °C View Scheme
参考文献
Lewis, Ian; Bauer, Wilfried; Albert, Rainer; Chandramouli, Nagarajan; Pless, Janos; Weckbecker, Gisbert; Bruns, Christian
Journal of Medicinal Chemistry, 2003 , vol. 46, # 12 p. 2334 - 2344
反应条件
sodium hydroxide in 1,4-dioxane
参考文献
Lewis, Ian; Bauer, Wilfried; Albert, Rainer; Chandramouli, Nagarajan; Pless, Janos; Weckbecker, Gisbert; Bruns, Christian
Journal of Medicinal Chemistry, 2003 , vol. 46, # 12 p. 2334 - 2344
