5-[(4-溴苯基氨基)亚甲基]-2,2-二甲基-1,3-二噁烷-4,6-二酮合成路线 （共 11 条）
反应条件
2,2-Dimethyl-[1,3]dioxane-4,6-dione in ethanol T=85°C; 4 h;
参考文献
CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.; XI, Ning; LI, Zhuo; WANG, Tingjin; WU, Zuping; WEN, Qiuling
Patent: WO2014/22128 A1, 2014 ;
Location in patent: Paragraph 0144; 0145; 0153 ;
反应条件
trimethyl orthoformate T=50°C; 2 h; Reflux;
参考文献
Wang, Min; Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1569 - 1574
反应条件
1: 2,2-Dimethyl-[1,3]dioxane-4,6-dione; trimethyl orthoformate 2 h; Heating; 2: 4-bromo-aniline 6 h; Heating;
参考文献
Beifuss, Uwe; Schniske, Ursula; Feder, Gerald
Tetrahedron, 2001 , vol. 57, # 6 p. 1005 - 1013
反应条件
1: 3 h / Reflux; Inert atmosphere 2: trimethyl orthoformate / 2 h / 50 °C / Reflux View Scheme
参考文献
Wang, Min; Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1569 - 1574
反应条件
1: diphenylether / 0.25 h / 245 - 250 °C / Inert atmosphere 2: trichlorophosphate / N,N-dimethyl-formamide / 2 h / Reflux 3: hydrogenchloride / tetrahydrofuran; diethyl ether / 0.5 h / 20 °C 4: sodium iodide / anhydrous propionitrile / 96 h / Reflux 5: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / 1,4-dioxane / Reflux View Scheme
参考文献
Wang, Min; Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1569 - 1574
反应条件
1: diphenylether / 0.25 h / 245 - 250 °C / Inert atmosphere 2: trichlorophosphate / N,N-dimethyl-formamide / 2 h / Reflux 3: hydrogenchloride / tetrahydrofuran; diethyl ether / 0.5 h / 20 °C View Scheme
参考文献
CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.; XI, Ning; LI, Zhuo; WANG, Tingjin; WU, Zuping; WEN, Qiuling
Patent: WO2014/22128 A1, 2014 ;
反应条件
1: diphenylether / 0.25 h / 245 - 250 °C / Inert atmosphere 2: trichlorophosphate / N,N-dimethyl-formamide / 2 h / Reflux 3: hydrogenchloride / tetrahydrofuran; diethyl ether / 0.5 h / 20 °C 4: sodium iodide / anhydrous propionitrile / 96 h / Reflux View Scheme
参考文献
CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.; XI, Ning; LI, Zhuo; WANG, Tingjin; WU, Zuping; WEN, Qiuling
Patent: WO2014/22128 A1, 2014 ;
反应条件
1: 1,2-dichloro-benzene / 6.5 h / 0 - 188 °C 2: trichlorophosphate / toluene / 4 h / 115 °C View Scheme
参考文献
CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.; XI, Ning; LI, Zhuo; WANG, Tingjin; WU, Zuping; WEN, Qiuling
Patent: WO2014/22128 A1, 2014 ;
反应条件
1: diphenylether / 0.25 h / 245 - 250 °C / Inert atmosphere 2: trichlorophosphate / N,N-dimethyl-formamide / 2 h / Reflux 3: hydrogenchloride / tetrahydrofuran; diethyl ether / 0.5 h / 20 °C 4: sodium iodide / anhydrous propionitrile / 96 h / Reflux 5: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / 1,4-dioxane / Reflux 6: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; potassium acetate / 1,4-dioxane / Reflux 7: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; sodium carbonate / 1,4-dioxane / Reflux View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 4 p. 1569 - 1574
反应条件
diphenylether T=245 - 250°C; 0.25 h; Inert atmosphere;
参考文献
Wang, Min; Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1569 - 1574
