1: (1S,2R)-2-(tert-butoxycarbonylamino)cyclohexan-1-ol With hydrogenchloride in diethyl ether
T=25°C; Substitution; 21 h;
2: benzyl chloroformate With sodium hydrogencarbonate in dichloromethane; water
T=25°C; Substitution; 3 h; Further stages.;
参考文献
Ohkuma, Takeshi; Ishii, Dai; Takeno, Hiroshi; Noyori, Ryoji
Journal of the American Chemical Society, 2000 , vol. 122, # 27 p. 6510 - 6511
1: benzyl 4-chlorobenzoyloxycarbamate With osmium(VIII) oxide; (DHQ)2-PHAL in acetonitrile
T=20°C; 0.166667 h;
2: cyclohexene in water; acetonitrile
T=20°C; 3 h; optical yield given as percent eeenantioselective reaction;
参考文献
Harris, Lawrence; Mee, Simon P. H.; Furneaux, Richard H.; Gainsford, Graeme J.; Luxenburger, Andreas
Journal of Organic Chemistry, 2011 , vol. 76, # 2 p. 358 - 372
(DHQD)2PHAL; potassium dioxotetrahydroxoosmate(VI); water in propan-1-ol
2 h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Li, Guigen; Angert, Hubert H.; Sharpless, K. Barry
Angewandte Chemie, 1996 , vol. 108, # 23/24 p. 2995 - 2999
