5-甲基-2-苯基-1,3--恶唑-4-甲酸合成路线 （共 30 条）
反应条件
hydrogen; palladium on activated charcoal in methanol P=760.051 Torr; 2 h;
参考文献
Journal of Organic Chemistry, , vol. 73, # 3 p. 1018 - 1024
反应条件
1: With sodium hydroxide in methanol 2: With potassium hydrogensulfate in methanol pH=2 - 3;
参考文献
Tetrahedron, , vol. 66, # 45 p. 8672 - 8680
反应条件
1.1: Deoxo-Fluor / CH2Cl2 / -20 °C 1.2: BrCCl3; DBU / CH2Cl2 / 2 - 3 °C 2.1: H2 / Pd/C / methanol; ethyl acetate / 20 °C / 760.05 Torr View Scheme
参考文献
Organic Letters, , vol. 9, # 9 p. 1683 - 1685
反应条件
sodium hypobromide in 1,4-dioxane
参考文献
Journal of the American Chemical Society, , vol. 97, p. 6484 - 6491
反应条件
1.1: Et3N; EDC / CH2Cl2 / 20 °C 2.1: Deoxo-Fluor / CH2Cl2 / -20 °C 2.2: BrCCl3; DBU / CH2Cl2 / 2 - 3 °C 3.1: H2 / Pd/C / methanol; ethyl acetate / 20 °C / 760.05 Torr View Scheme
参考文献
Organic Letters, , vol. 9, # 9 p. 1683 - 1685
参考文献
Chem. Penicillin, <Princeton 1949>, S. 688, 706
反应条件
1: DIEA / CH2Cl2 2: Burgess reagent / tetrahydrofuran / 2 h / Heating 3: DBU; BrCCl3 / CH2Cl2 4: H2 / Pd/C / methanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 4 p. 1075 - 1078
反应条件
1: PCl5; diethyl ether 2: aqueous NaOH View Scheme
参考文献
Chem. Penicillin, <Princeton 1949>, S. 688, 706
反应条件
trichloromonobromomethane; 1,8-diazabicyclo[5.4.0]undec-7-ene in dichloromethane T=0 - 20°C;
参考文献
European Journal of Medicinal Chemistry, , vol. 45, # 5 p. 1703 - 1716
反应条件
1: 89 percent / Dess-Martin periodinane / CH2Cl2 / 0.17 h / 22 °C 2: 74 percent / Ph3P, I2, Et3N / CH2Cl2 / 0.33 h / 22 °C 3: 95 percent / aq. NaOH / methanol / 2 h / 22 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 5, # 1 p. 165 - 177
