5,11-二氢-6H-吲哚并[3,2-c]喹啉-6-酮合成路线 （共 35 条）
反应条件
1: diphenyl phosphoryl azide; triethylamine / toluene / 1.5 h / 100 °C / Inert atmosphere; Microwave irradiation 2: 1,2-dichloro-benzene / 0.25 h / 180 °C / Inert atmosphere View Scheme
参考文献
Tetrahedron, , vol. 68, # 22 p. 4274 - 4279
反应条件
1.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / ethylene glycol dimethyl ether; water / 12 h / Inert atmosphere; Reflux 2.1: lithium hydroxide hydrate / tetrahydrofuran; water / 12 h / 60 °C 2.2: 20 °C 3.1: diphenyl phosphoryl azide; triethylamine / toluene / 1.5 h / 100 °C / Inert atmosphere; Microwave irradiation 4.1: 1,2-dichloro-benzene / 0.25 h / 180 °C / Inert atmosphere View Scheme
参考文献
Tetrahedron, , vol. 68, # 22 p. 4274 - 4279
反应条件
1.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / ethylene glycol dimethyl ether; water / 12 h / Inert atmosphere; Reflux 2.1: lithium hydroxide hydrate / tetrahydrofuran; water / 12 h / 60 °C 2.2: 20 °C 3.1: diphenyl phosphoryl azide; triethylamine / toluene / 1.5 h / 100 °C / Inert atmosphere; Microwave irradiation 4.1: 1,2-dichloro-benzene / 0.25 h / 180 °C / Inert atmosphere View Scheme
参考文献
Tetrahedron, , vol. 68, # 22 p. 4274 - 4279
反应条件
1: sodium hydroxide / tetrahydrofuran / 2 h / 20 °C 2: sodium hydroxide / water; ethanol / 15 h / 80 °C 3: thionyl chloride / dichloromethane / 1 h / 20 °C 4: dichloromethane / 2 h / -20 - 20 °C 5: [bis(acetoxy)iodo]benzene / 1,2-dichloro-ethane / 1 h / 20 °C 6: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 120 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 78, # 24 p. 12750 - 12759
反应条件
1: acetic acid / 20 h / 80 °C / |Inert atmosphere 2: palladium diacetate; copper diacetate; potassium carbonate / N,N-dimethyl-formamide / 15 h / 80 °C / |Inert atmosphere 3: sodium hydroxide / tetrahydrofuran / 2 h / 20 °C 4: sodium hydroxide / water; ethanol / 15 h / 80 °C 5: thionyl chloride / dichloromethane / 1 h / 20 °C 6: dichloromethane / 2 h / -20 - 20 °C 7: [bis(acetoxy)iodo]benzene / 1,2-dichloro-ethane / 1 h / 20 °C 8: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 120 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 78, # 24 p. 12750 - 12759
反应条件
1: palladium diacetate; copper diacetate; potassium carbonate / N,N-dimethyl-formamide / 15 h / 80 °C / |Inert atmosphere 2: sodium hydroxide / tetrahydrofuran / 2 h / 20 °C 3: sodium hydroxide / water; ethanol / 15 h / 80 °C 4: thionyl chloride / dichloromethane / 1 h / 20 °C 5: dichloromethane / 2 h / -20 - 20 °C 6: [bis(acetoxy)iodo]benzene / 1,2-dichloro-ethane / 1 h / 20 °C 7: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 120 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 78, # 24 p. 12750 - 12759
反应条件
1: [bis(acetoxy)iodo]benzene / 1,2-dichloro-ethane / 1 h / 20 °C 2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 120 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 78, # 24 p. 12750 - 12759
反应条件
1: acetic acid / 20 h / 80 °C / |Inert atmosphere 2: palladium diacetate; copper diacetate; potassium carbonate / N,N-dimethyl-formamide / 15 h / 80 °C / |Inert atmosphere 3: sodium hydroxide / tetrahydrofuran / 2 h / 20 °C 4: sodium hydroxide / water; ethanol / 15 h / 80 °C 5: thionyl chloride / dichloromethane / 1 h / 20 °C 6: dichloromethane / 2 h / -20 - 20 °C 7: [bis(acetoxy)iodo]benzene / 1,2-dichloro-ethane / 1 h / 20 °C 8: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 120 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 78, # 24 p. 12750 - 12759
反应条件
1: sodium hydroxide / water; ethanol / 15 h / 80 °C 2: thionyl chloride / dichloromethane / 1 h / 20 °C 3: dichloromethane / 2 h / -20 - 20 °C 4: [bis(acetoxy)iodo]benzene / 1,2-dichloro-ethane / 1 h / 20 °C 5: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 120 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 78, # 24 p. 12750 - 12759
反应条件
1: trifluoroacetic acid / dichloromethane / 12 h / 20 °C / Inert atmosphere 2: lithium hydroxide hydrate / tetrahydrofuran; water / 12 h / 60 °C 3: diphenyl phosphoryl azide; triethylamine / benzene / 1.5 h / 50 °C / Inert atmosphere 4: 1,2-dichloro-benzene / 0.25 h / 180 °C / Inert atmosphere View Scheme
参考文献
Tetrahedron, , vol. 68, # 22 p. 4274 - 4279
