(E)-1,3-二乙基-6-氨基-5-(3,4-二甲氧基苯丙烯酰基)氨基尿嘧啶合成路线 （共 3 条）
反应条件
1: in acetonitrile Microwave irradiation; 2: With ammonium sulfate; hexamethyl-silane in acetonitrile T=160°C; 5 h; Microwave irradiation;
参考文献
Joerg, Manuela; Shonberg, Jeremy; Mak, Frankie S.; Miller, Neil D.; Yuriev, Elizabeth; Scammells, Peter J.; Capuano, Ben
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 11 p. 3427 - 3433
反应条件
1: 92 percent / 1,1,1,3,3,3-hyxamethyldisilazane; (NH4)2SO4 / 4 h / 170 - 180 °C 2: 95 percent / potassium carbonate / dimethylformamide / 0.5 h / 20 °C View Scheme
参考文献
Joerg, Manuela; Shonberg, Jeremy; Mak, Frankie S.; Miller, Neil D.; Yuriev, Elizabeth; Scammells, Peter J.; Capuano, Ben
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 11 p. 3427 - 3433
反应条件
<b>Multi-step reaction with 2 steps<br /> </b>1: thionyl chloride / toluene / 16 h / 75 °C<br />2: pyridine / dichloromethane / 24 h / 20 °C<br /> <br />
参考文献
Joerg, Manuela; Shonberg, Jeremy; Mak, Frankie S.; Miller, Neil D.; Yuriev, Elizabeth; Scammells, Peter J.; Capuano, Ben Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 11 p. 3427 - 3433
