反应条件
1.1: 86 percent / tBuOK / hexamethylphosphoric acid triamide / 18 h / 20 °C
2.1: 78 percent / nBu3SnH; AIBN / toluene / 4 h / 90 °C
3.1: 100 percent / LiAlH4 / tetrahydrofuran / 3 h / 0 - 20 °C
4.1: 78 percent / Dess-Martin periodinane / CH2Cl2 / 3 h / 20 °C
5.1: MgSO4 / CH2Cl2 / 48 h / 20 °C
6.1: Et3N / CH2Cl2
7.1: diethyl ether / -78 - -30 °C
7.2: H5IO6; MeNH2 / methanol; H2O / 20 °C
View Scheme
参考文献
Chao, Jianhua; Taveras, Arthur G.; Chao, Jianping; Aki, Cynthia; Dwyer, Michael; Yu, Younong; Purakkattle, Biju; Rindgen, Diane; Jakway, James; Hipkin, William; Fosetta, James; Fan, Xuedong; Lundell, Daniel; Fine, Jay; Minnicozzi, Michael; Phillips, Jonathan; Merritt, J. Robert
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 13 p. 3778 - 3783
