Fmoc-L-Asn(Trt)-L-Asn(Trt)-NH(CH2)6CONH(CH2)3-silica gel in chloroform

暂无反应条件数据

hydrazine hydrate T=170 - 180°C; 48 h;

(-)-sparteine in methanol 4 h; Ambient temperature;

hydrogenchloride; tin(ll) chloride

(R)-3,3′-bis[3,5-bis(trifluoromethyl)phenyl]-1,1′-binaphthyl-2,2′-diyl hydrogenphosphate in toluene T=-20°C; 24 h; Inert atmosphereMolecular sieve; Reagent/catalystSolventTime; Optical yield = 86 percent ee; enantioselective reaction;

CG-50 resin in chloroform T=20°C; 22 h; Inert atmosphere; Overall yield = 51 percent; enantioselective reaction;

1: indium tribromide; triethylsilane / N,N-dimethyl-formamide / 60 °C / |Schlenk technique; |Inert atmosphere 2: zinc; ammonium chloride / tetrahydrofuran / 0.5 h / 0 - 20 °C / |Schlenk technique 3: (R)-3,3′-bis[3,5-bis(trifluoromethyl)phenyl]-1,1′-binaphthyl-2,2′-diyl hydrogenphosphate / chloroform / 66 h / -50 °C / |Inert atmosphere View Scheme

1: zinc; ammonium chloride / tetrahydrofuran / 0.5 h / 0 - 20 °C / |Schlenk technique 2: (R)-3,3′-bis[3,5-bis(trifluoromethyl)phenyl]-1,1′-binaphthyl-2,2′-diyl hydrogenphosphate / chloroform / 66 h / -50 °C / |Inert atmosphere View Scheme

1: triethylamine / dichloromethane / 0 - 20 °C 2: tris-(dibenzylideneacetone)dipalladium(0); t-Bu Brett Phos; sodium nitrite; TDA / tert-butyl alcohol / 130 °C / |Schlenk technique; |Inert atmosphere 3: indium tribromide; triethylsilane / N,N-dimethyl-formamide / 60 °C / |Schlenk technique; |Inert atmosphere 4: zinc; ammonium chloride / tetrahydrofuran / 0.5 h / 0 - 20 °C / |Schlenk technique 5: (R)-3,3′-bis[3,5-bis(trifluoromethyl)phenyl]-1,1′-binaphthyl-2,2′-diyl hydrogenphosphate / chloroform / 66 h / -50 °C / |Inert atmosphere View Scheme