2-(2-溴乙基)-1,3-二恶烷合成路线 （共 57 条）
反应条件
1: 2,4-dioxo-5-[(p-hydroxyphenyl)-methyl]thiazolidine With sodium hydride in N,N-dimethyl-formamide T=20°C; Metallation; 2 h; 2: 2-(1,3-dioxa-2-cyclopentyl)-ethyl bromide in N,N-dimethyl-formamide T=50°C; Condensation; 5 h; Further stages.;
参考文献
Oguchi; Wada; Honma; Tanaka; Kaneko; Sakakibara; Ohsumi; Serizawa; Fujiwara; Horikoshi; Fujita
Journal of Medicinal Chemistry, 2000 , vol. 43, # 16 p. 3052 - 3066
反应条件
Amberlite IR-900 (nitrite form) in benzene T=20°C; 36 h;
参考文献
Crumbie, Robyn L.; Nimitz, Jonathan S.; Mosher, Harry S.
Journal of Organic Chemistry, 1982 , vol. 47, # 21 p. 4040 - 4045
反应条件
magnesium in tetrahydrofuran; ethyl acetate
参考文献
Rhone-Poulenc Agrochimie
Patent: US4863943 A1, 1989 ;
反应条件
in acetonitrile 24 h;
参考文献
Dirat, Olivier; Kouklovsky, Cyrille; Langlois, Yves
Journal of Organic Chemistry, 1998 , vol. 63, # 19 p. 6634 - 6642
参考文献
BRACCO S.p.A.; DIBRA S.p.A.
Patent: EP760683 B1, 2000 ;
反应条件
1: 90 percent / sodium azide, tetra-n-hexylammonium bromide / H2O / 2 h 2: 1.) Ph3P, 2.) H2O / 1) THF, 3 h, below 40 deg C, 20 deg C (1 h); 2) 1 h, 20 deg C View Scheme
参考文献
Crumbie, Robyn L.; Nimitz, Jonathan S.; Mosher, Harry S.
Journal of Organic Chemistry, 1982 , vol. 47, # 21 p. 4040 - 4045
反应条件
copper(l) iodide; lithium methanolate; triphenylphosphine in N,N-dimethyl-formamide T=25°C; 18 h; Inert atmosphere;
参考文献
Yang, Chu-Ting; Zhang, Zhen-Qi; Tajuddin, Hazmi; Wu, Chen-Cheng; Liang, Jun; Liu, Jing-Hui; Fu, Yao; Czyzewska, Maria; Steel, Patrick G.; Marder, Todd B.; Liu, Lei
Angewandte Chemie - International Edition, 2012 , vol. 51, # 2 p. 528 - 532
反应条件
magnesium; copper(I) bromide 1.) THF, 30 deg C, 30 min, 2.) THF, 20 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Heterocycles, , vol. 26, # 12 p. 3141 - 3151
反应条件
sodium azide in dimethyl sulfoxide T=20°C; 14 h;
参考文献
Diez-Gonzalez, Silvia; Escudero-Adan, Eduardo C.; Benet-Buchholz, Jordi; Stevens, Edwin D.; Slawin, Alexandra M. Z.; Nolan, Steven P.
Dalton Transactions, 2010 , vol. 39, # 32 p. 7595 - 7606
参考文献
Rossy, Cybille; Majimel, Jerome; Delapierre, Mona Treguer; Fouquet, Eric; Felpin, Francois-Xavier
Journal of Organometallic Chemistry, 2014 , vol. 755, p. 78 - 85
