2-(2-溴乙基)-1,3-二恶烷合成路线 （共 57 条）
反应条件
magnesium
1.) THF, r.t., 1h; 2.) THF, 0 deg C, 30 min; Yield given. Multistep reaction;
参考文献
Rigby,J.H.; Wilson,J.Z.
Journal of the American Chemical Society, 1984 , vol. 106, p. 8217
反应条件
magnesium in tetrahydrofuran
1.5 h; Ambient temperature;
参考文献
Lucchesini, Francesco
Tetrahedron, 1992 , vol. 48, # 45 p. 9951 - 9966
反应条件
1: Mg / tetrahydrofuran / 1 h
2: tetrahydrofuran / 1.5 h
View Scheme
参考文献
Tsuie, Barbara; Reddinger, Jerry L.; Sotzing, Gregory A.; Soloducho, Jadwiga; Katritzky, Alan R.; Reynolds, John R.
Journal of Materials Chemistry, 1999 , vol. 9, # 9 p. 2189 - 2200
反应条件
1.1: iodine; magnesium; 1,2-dibromoethane / tetrahydrofuran / 1 h
1.2: 65 percent / tetrahydrofuran / -78 - 20 °C
2.1: n-BuLi / tetrahydrofuran / 1 h / -78 °C
2.2: 65 percent / tetrahydrofuran / 3 h / -78 °C
View Scheme
参考文献
Liu, Xuan; West
Chemical Communications, 2006 , # 48 p. 5036 - 5038
反应条件
n-butyllithium
1) THF, -78 deg C, 4 h; 2) HMPA, -78 deg C--> room temp., then room temp., 12 h; Multistep reaction;
参考文献
Dunach,E.; Halterman,R.L.; Vollhardt,K.P.
Journal of the American Chemical Society, 1985 , vol. 107, p. 1664
反应条件
1: 90 percent / LiNH2, NH3 / 4 h
2: 1.) CH3SO2Cl, Et3N, 2.) LiCl / 1.) CH2Cl2, -40 deg C, 4 h, room temperature, 2.) DMF, 60 deg C to room temperature, 12 h
View Scheme
参考文献
Deslongchamps, Pierre; Roy, Bernard L.
Canadian Journal of Chemistry, 1986 , vol. 64, p. 2068 - 2075
反应条件
sodium chloride in N-methyl-acetamide
参考文献
Roussel Uclaf
Patent: US5656607 A1, 1997 ;
反应条件
1: 40.7 g / 1.) n-BuLi / 1.) THF, -70 deg C, 2.5 h, 2.) -70 deg C, 1.5 h
2: Li / liquid ammonia; diethyl ether / 4 h / -25 °C
View Scheme
参考文献
Grigorieva, N. Ya.; Avrutov, I. M.; Semenovsky, A. V.
Tetrahedron Letters, 1983 , vol. 24, # 49 p. 5531 - 5534
反应条件
hydrogenchloride in chloroform
T=20°C; 24 h;
参考文献
Benedetti, Fabio; Stirling, Charles J.M.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1986 , p. 605 - 612
反应条件
sodium hydride in N,N-dimethyl-formamide
Heating;
参考文献
Valiulin, Roman V.; Kutateladze, Andrei G.
Journal of Organic Chemistry, 2008 , vol. 73, # 16 p. 6393 - 6396
