2-(2-溴乙基)-1,3-二恶烷合成路线 （共 57 条）
反应条件
n-butyllithium
1) THF, -78 deg C, 4 h; 2) HMPA, -78 deg C--> room temp., then room temp., 12 h; Multistep reaction;
参考文献
Dunach,E.; Halterman,R.L.; Vollhardt,K.P.
Journal of the American Chemical Society, 1985 , vol. 107, p. 1664
反应条件
sodium ethanolate; sodium amide
1.) NH3 (liq.)-THF, -33 deg C, 3 h, 2.) NH3(liq.)-THF-EtOH, -78 deg C, 2 h; Yield given. Multistep reaction;
参考文献
Shishido, Kozo; Saitoh, Tadamasa; Fukumoto, Keiichiro; Kametani, Tetsui
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 2139 - 2146
反应条件
1: 55 percent / NaNO2 / dimethylformamide / 7 h / Ambient temperature
2: 79 percent / Amberlist A 21 / 4 h
3: 71 percent / pyridinium chlorochromate, molecular sieves / CH2Cl2 / 36 h / Ambient temperature
View Scheme
参考文献
Rosini, Goffredo; Ballini, Roberto; Petrini, Marino; Sorrenti, Pietro
Tetrahedron, 1984 , vol. 40, # 19 p. 3809 - 3814
反应条件
P(t-Bu)2Me; tetrabutyl ammonium fluoride; palladium (II) bromide in tetrahydrofuran
T=20°C; Hiyama coupling; 14 h;
参考文献
Lee, Jae-Young; Fu, Gregory C.
Journal of the American Chemical Society, 2003 , vol. 125, # 19 p. 5616 - 5617
反应条件
1,3-bis-(diphenylphosphino)propane; cobalt(II) chloride in tetrahydrofuran
T=-15°C; 0.5 h;
参考文献
Ohmiya, Hirohisa; Wakabayashi, Katsuyu; Yorimitsu, Hideki; Oshima, Koichiro
Tetrahedron, 2006 , vol. 62, # 10 p. 2207 - 2213
反应条件
N,N,N',N,-tetramethylethylenediamine; C34H46Cl4N10Ni2O2 in tetrahydrofuran
T=20°C; 1.33333 h; Inert atmosphereSchlenk technique;
参考文献
Xue, Fei; Zhao, Jin; Hor, T. S. Andy
Dalton Transactions, 2013 , vol. 42, # 14 p. 5150 - 5158
反应条件
1: 80.6 percent / benzyltrimethylammonium chloride / H2O / 4 h / 90 °C
2: 79.2 percent / LAH / diethyl ether / 22 h / Heating
View Scheme
参考文献
Shimizu; Ishikawa; Komoda; Nakajima
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 3 p. 909 - 914
反应条件
N-benzyl-N,N,N-trimethyl-ammonium chloride in water
T=90°C; 4 h;
参考文献
Shimizu; Ishikawa; Komoda; Nakajima
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 3 p. 909 - 914
反应条件
in N-methyl-acetamide; dichloromethane; water
参考文献
Gensia, Inc.
Patent: US5775329 A1, 1998 ;
反应条件
in water; ethylene glycol
T=100°C; 3 h;
参考文献
Nakao, Yoshiaki; Yada, Akira; Hiyama, Tamejiro
Journal of the American Chemical Society, 2010 , vol. 132, # 29 p. 10024 - 10026
