2-(2-溴乙基)-1,3-二恶烷合成路线 （共 57 条）
参考文献
Nycomed Imaging AS
Patent: US5531978 A1, 1996 ;
反应条件
1: copper(l) iodide; lithium methanolate / N,N-dimethyl-formamide / 24 h / 20 °C / |Glovebox
2: KHF2 / N,N-dimethyl-formamide; water / 0.5 h / 0 °C / |Glovebox
3: caesium carbonate; mono(bis(di-tert-butyl(4-(dimethylamino)phenyl)phosphonio)palladium(II))dichloride / water; toluene / 14 h / 100 °C / |Inert atmosphere
View Scheme
参考文献
Fleury-Bregeot, Nicolas; Oehlrich, Daniel; Rombouts, Frederik; Molander, Gary A.
Organic Letters, 2013 , vol. 15, # 7 p. 1536 - 1539
反应条件
ammonium hydroxide in N,N-dimethyl-formamide
参考文献
Beecham Group plc
Patent: US4971975 A1, 1990 ;
反应条件
sodium ethanolate in ethanol
13 h; Heating;
参考文献
Roush, William R.; Myers, Andrew G.
Journal of Organic Chemistry, 1981 , vol. 46, # 7 p. 1509 - 1511
反应条件
1: T=160°C; 18 h;
2: With hydrogenchloride in water
T=20°C; 0.25 h; RefluxInert atmosphere;
参考文献
INDUSTRIAL RESEARCH LIMITED; ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY; CLINCH, Keith; CRUMP, Douglas Ronald; EVANS, Gary Brian; HAZLETON, Keith Zachary; MASON, Jennifer Mary; SCHRAMM, Vern L.; TYLER, Peter Charles
Patent: WO2012/150866 A1, 2012 ;
Location in patent: Page/Page column 44-45 ;
WO 2012/150866 A1
反应条件
(i) Mg, (ii) /BRN= 745312/, THF, Et2O; Multistep reaction;
参考文献
Loozen,H.J.J. et al.
Journal of Organic Chemistry, 1975 , vol. 40, p. 892 - 894
反应条件
in N,N-dimethyl-formamide
T=80°C; 12 h;
参考文献
Gaoni, Yehiel; Tomazic, Alenka; Potgieter, Eleonora
Journal of Organic Chemistry, 1985 , vol. 50, # 16 p. 2943 - 2947
