4-羟基-6-丙基吡喃-2-酮合成路线 （共 10 条）
反应条件
1: 4-hydroxy-6-methyl-2H-pyran-2-one With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 1 h;
2: ethyl iodide in tetrahydrofuran; hexane
T=20°C; 12 h; Further stages.;
参考文献
Zhang, Xuejun; McLaughlin, Michael; Munoz, R. Lizeth P.; Hsung, Richard P.; Wang, Jiashi; Swidorski, Jacob
Synthesis, 2007 , # 5 p. 749 - 753
反应条件
n-butyllithium
Multistep reaction;
参考文献
Groutas, William C.; Stanga, Michael A.; Brubaker, Michael J.; Huang, Tien L.; Moi, Min K.; Carroll, Robert T.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 8 p. 1106 - 1109
反应条件
type III polyketide synthase RppA from S. griseus; 2-hydroxyethanethiol in various solvent(s)
T=37°C; pH=7.5; 2 h;
参考文献
Jeong, Jae-Cheol; Srinivasan, Aravind; Grueschow, Sabine; Bach, Horacio; Sherman, David H.; Dordick, Jonathan S.
Journal of the American Chemical Society, 2005 , vol. 127, # 1 p. 64 - 65
反应条件
1: 6-Methyl-4-(trimethylsiloxy)-2H-pyran-2-on With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 1 h;
2: ethyl iodide in tetrahydrofuran; hexane
T=20°C; 20 h; Further stages.;
参考文献
Zhang, Xuejun; McLaughlin, Michael; Munoz, R. Lizeth P.; Hsung, Richard P.; Wang, Jiashi; Swidorski, Jacob
Synthesis, 2007 , # 5 p. 749 - 753
反应条件
1.1: 0.5 h / 80 °C
2.1: butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C
2.2: 4.07 g / tetrahydrofuran; hexane / 20 h / 20 °C
View Scheme
参考文献
Zhang, Xuejun; McLaughlin, Michael; Munoz, R. Lizeth P.; Hsung, Richard P.; Wang, Jiashi; Swidorski, Jacob
Synthesis, 2007 , # 5 p. 749 - 753
反应条件
alkylresorcylic acid synthase, ARAS2
T=30°C; pH=7; 0.333333 h; aq. phosphate bufferEnzymatic reaction;
参考文献
Matsuzawa, Miku; Katsuyama, Yohei; Funa, Nobutaka; Horinouchi, Sueharu
Phytochemistry, 2010 , vol. 71, # 10 p. 1059 - 1067
参考文献
Effenberger, Franz; Schoenwaelder, Karl-Heinz; Stezowski, John J.
Angewandte Chemie, 1982 , vol. 94, # 11 p. 863 - 864
反应条件
potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride
1) Et2O, -19 deg C, 2 h, 2) Et2O, r.t., 4 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Effenberger, Franz; Schoenwaelder, Karl-Heinz
Chemische Berichte, 1984 , vol. 117, # 11 p. 3270 - 3279
反应条件
1: With recombinant N-His-tagged hexaketide synthase of Drosophyllum lusitanicum Link
pH=7.0; aq. bufferEnzymatic reaction;
2: Acidic aq. solution;
参考文献
Jindaprasert, Aphacha; Springob, Karin; Schmidt, Juergen; De-Eknamkul, Wanchai; Kutchan, Toni M.
Phytochemistry, 2008 , vol. 69, # 18 p. 3043 - 3053
反应条件
sodium carbonate in acetone
Heating;
参考文献
Effenberger, Franz; Schoenwaelder, Karl-Heinz
Chemische Berichte, 1984 , vol. 117, # 11 p. 3270 - 3279
