1: (4S)-4,6-bis{[tert-butyl(dimethyl)silyl]oxy}-3,3-dimethylhexan-2-one With lithium diisopropyl amide in tetrahydrofuran
T=-78 - -15°C; 2 h;
2: methyl iodide in tetrahydrofuran
T=-78 - -40°C;
参考文献
Storer, R. Ian; Takemoto, Toshiyasu; Jackson, Philip S.; Brown, Dearg S.; Baxendale, Ian R.; Ley, Steven V.
Chemistry - A European Journal, 2004 , vol. 10, # 10 p. 2529 - 2547
1.1: 100 percent / pentane / 3.5 h / 0 °C
2.1: LDA / hexane; tetrahydrofuran / 0.17 h / -78 - -15 °C
2.2: 94 percent / hexane; tetrahydrofuran / 2 h / -78 - -40 °C
View Scheme
参考文献
Storer, R. Ian; Takemoto, Toshiyasu; Jackson, Philip S.; Brown, Dearg S.; Baxendale, Ian R.; Ley, Steven V.
Chemistry - A European Journal, 2004 , vol. 10, # 10 p. 2529 - 2547
1: PhSO2Et With n-butyllithium in tetrahydrofuran
T=-78°C; 1.5 h;
2: (-)-methyl (3S)-3,5-bis{[tert-butyl(dimethyl)silyl]oxy}-2,2-dimethylpentanoate in tetrahydrofuran
T=-78 - 20°C; Further stages;
参考文献
Reiff, Emily A.; Nair, Sajiv K.; Henri, John T.; Greiner, Jack F.; Reddy, Bollu S.; Chakrasali, Ramappa; David, Sunil A.; Chiu, Ting-Lan; Amin, Elizabeth A.; Himes, Richard H.; Vander Velde, David G.; Georg, Gunda I.
Journal of Organic Chemistry, 2010 , vol. 75, # 1 p. 86 - 94
