2,3-二氟-6-甲氧基苯甲醛合成路线 （共 6 条）
反应条件
lithium diisopropyl amide in tetrahydrofuran
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/43904 A1, 2004 ;
Location in patent: Page 39 - 40 ;
WO 2004/043904 A1
反应条件
1: 1,2-difluoro-4-methoxy-benzene With lithium diisopropyl amide in tetrahydrofuran T=-75°C; 1 h; 2: N,N-dimethyl-thioformamide in tetrahydrofuran; water; acetic acid T=-70 - 10°C; 0.166667 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/43903 A1, 2004 ;
Location in patent: Page 40 - 41 ;
WO 2004/043903 A1
反应条件
1: With magnesium chloride in 2-methyl tetrahydrofuran; water 2: With lithium diisopropyl amide in 2-methyl tetrahydrofuran; hexane; water TemperatureTime;
参考文献
Rawalpally, Thimma; Ji, Yaohui; Shankar, Ashish; Edwards, William; Allen, Joshua; Jiang, Yong; Cleary, Thomas P.; Pierce, Michael E.
Organic Process Research and Development, 2008 , vol. 12, # 6 p. 1293 - 1298
反应条件
1: K2CO3 / acetone / 5 h / 60 °C 2: 1.) BuLi / 1.) hexane, THF, -65 degC, 0.5 h, 2.) hexane, THF, from -65 deg C to RT View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 21 p. 4261 - 4274
反应条件
1: With potassium hydroxide; dihydrogen peroxide in water T=70°C; 2 h; 2: With hydrogenchloride in water pH=2;
参考文献
ASTEX THERAPEUTICS LIMITED
Patent: WO2006/77414 A1, 2006 ;
Location in patent: Page/Page column 148 ;
WO 2006/077414 A1
反应条件
ammonia; sulfur in 2-methoxy-ethanol; water
参考文献
N.V. Organon
Patent: US2007/112019 A1, 2007 ;
Location in patent: Page/Page column 10/1 ;
