(2-甲基-2-苯基-丙基)乙酸酯合成路线 （共 19 条）
反应条件
1: NO2/HNO3, Ac2O 2: pyridine View Scheme
参考文献
Tanida,H. et al.
Journal of Organic Chemistry, 1969 , vol. 34, p. 1086 - 1089
反应条件
1: NO2/HNO3, Ac2O 2: H2 / PtO2 View Scheme
参考文献
Tanida,H. et al.
Journal of Organic Chemistry, 1969 , vol. 34, p. 1086 - 1089
反应条件
1: 63.5 percent / AlCl3 / CS2 / 1.5 h / 0 - 5 °C 2: 68 percent / p-TsOH*H2O / benzene / 24 h / Heating 3: 99 percent / NaOH; MeOH / 0.5 h / 20 °C 4: 89 percent / Jones reagent / acetone / 0 °C 5: 92 percent / diethyl ether / 0 °C 6: 89 percent / HCl; H2O / tetrahydrofuran / 15 h / 20 °C 7: 95 percent / NaBH4 / methanol; tetrahydrofuran / 0.5 h / 0 °C 8: 44 percent / K2CO3; KI / dimethylformamide; toluene / 7 h / Heating 9: 67.6 percent / NaOH; MeOH / 2 h / Heating View Scheme
参考文献
Ronggeng, Wang; Yougui, Zhao; Guanchao, Zhang
Research on Chemical Intermediates, 2013 , vol. 39, # 5 p. 2149 - 2155
反应条件
1.1: AlCl3, aluminium chloride / dichloromethane / 2.33 h / -5 - 0 °C 1.2: 5 h / 0 °C 2.1: methanol; sodium hydroxide / 4 h / 25 - 30 °C 3.1: water; acetic acid; potassium permanganate / acetone / 7 h / 25 - 45 °C 4.1: hydrogenchloride / 7 h / 40 - 45 °C View Scheme
参考文献
Ronggeng, Wang; Yougui, Zhao; Guanchao, Zhang
Research on Chemical Intermediates, 2013 , vol. 39, # 5 p. 2149 - 2155
反应条件
1: 63.5 percent / AlCl3 / CS2 / 1.5 h / 0 - 5 °C 2: 68 percent / p-TsOH*H2O / benzene / 24 h / Heating 3: 99 percent / NaOH; MeOH / 0.5 h / 20 °C 4: 89 percent / Jones reagent / acetone / 0 °C 5: 92 percent / diethyl ether / 0 °C 6: 89 percent / HCl; H2O / tetrahydrofuran / 15 h / 20 °C View Scheme
参考文献
Jubilant Organosys Limited
Patent: EP2289867 A2, 2011 ;
反应条件
1: 63.5 percent / AlCl3 / CS2 / 1.5 h / 0 - 5 °C 2: 68 percent / p-TsOH*H2O / benzene / 24 h / Heating 3: 99 percent / NaOH; MeOH / 0.5 h / 20 °C 4: 89 percent / Jones reagent / acetone / 0 °C 5: 92 percent / diethyl ether / 0 °C 6: 89 percent / HCl; H2O / tetrahydrofuran / 15 h / 20 °C 7: 95 percent / NaBH4 / methanol; tetrahydrofuran / 0.5 h / 0 °C 8: 44 percent / K2CO3; KI / dimethylformamide; toluene / 7 h / Heating View Scheme
参考文献
Di Giacomo, Barbara; Coletta, Donato; Natalini, Benedetto; Ni, Ming-Hong; Pellicciari, Roberto
Farmaco, 1999 , vol. 54, # 9 p. 600 - 610
反应条件
aluminium trichloride in dichloromethane T=-5 - 10°C; 19 h;
参考文献
Merrell Pharmaceuticals, Inc.
Patent: US6348597 B2, 2002 ;
Location in patent: Page column 87-88 ;
反应条件
1: γ-chlorobutyryl chloride With AlCl3, aluminium chloride in dichloromethane T=0 - 5°C; Inert atmosphere; 2: (2-acetoxy-1,1-dimethylethyl)benzene in dichloromethane T=0°C; Inert atmosphere;
参考文献
Jubilant Organosys Limited
Patent: EP2289867 A2, 2011 ;
Location in patent: Page/Page column 7 ;
反应条件
1: γ-chlorobutyraldehyde With AlCl3, aluminium chloride in dichloromethane T=-5 - 0°C; 2.33333 h; 2: (2-acetoxy-1,1-dimethylethyl)benzene in dichloromethane T=0°C; 5 h;
参考文献
Ronggeng, Wang; Yougui, Zhao; Guanchao, Zhang
Research on Chemical Intermediates, 2013 , vol. 39, # 5 p. 2149 - 2155
反应条件
1.1: AlCl3, aluminium chloride / dichloromethane / 0 - 5 °C / Inert atmosphere 1.2: 0 °C / Inert atmosphere 2.1: sodium hydroxide; methanol / 2 h / 20 °C 3.1: potassium permanganate; acetic acid / water; acetone / 0 - 20 °C View Scheme
参考文献
Ronggeng, Wang; Yougui, Zhao; Guanchao, Zhang
Research on Chemical Intermediates, 2013 , vol. 39, # 5 p. 2149 - 2155
