1-(Boc-氨基)-1-羟基甲基环己烷合成路线 （共 6 条）
反应条件
1: With triethylamine in tetrahydrofuran T=-10°C; 0.333333 h; 2: With sodium tetrahydroborate; water in tetrahydrofuran 1.5 h;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1698626 A1, 2006 ;
Location in patent: Page/Page column 142 ;
反应条件
1: 1-amino-1-cyclo-hexanecarboxylic acid With lithium aluminium tetrahydride in tetrahydrofuran T=70 - 80°C; 28 h; 2: di-tert-butyl dicarbonate With TEA in methanol T=20°C; 4 h;
参考文献
Mutulis, Felikss; Yahorava, Sviatlana; Mutule, Ilze; Yahorau, Aleh; Liepinsh, Edvards; Kopantshuk, Sergei; Veiksina, Santa; Tars, Kaspars; Belyakov, Sergey; Mishnev, Anatoly; Rinken, Ago; Wikberg, Jarl E. S.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 18 p. 4613 - 4626
反应条件
triethylamine in dichloromethane T=0 - 20°C;
参考文献
Steves, Janelle E.; Stahl, Shannon S.
Journal of the American Chemical Society, 2013 , vol. 135, # 42 p. 15742 - 15745
反应条件
lithium borohydride in tetrahydrofuran T=0 - 20°C;
参考文献
Shiau, Timothy P.; Houchin, Ashley; Nair, Satheesh; Xu, Ping; Low, Eddy; Najafi, Ramin (Ron); Jain, Rakesh
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 4 p. 1110 - 1114
参考文献
Chen, Kevin X.; Vibulbhan, Bancha; Yang, Weiying; Nair, Latha G.; Tong, Xiao; Cheng, Kuo-Chi; Njoroge, F. George
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 4 p. 1105 - 1109
反应条件
hydrogenchloride in 1,4-dioxane
T=20°C; 1 h;
参考文献
Mutulis, Felikss; Yahorava, Sviatlana; Mutule, Ilze; Yahorau, Aleh; Liepinsh, Edvards; Kopantshuk, Sergei; Veiksina, Santa; Tars, Kaspars; Belyakov, Sergey; Mishnev, Anatoly; Rinken, Ago; Wikberg, Jarl E. S.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 18 p. 4613 - 4626
