2-(乙酰氧基甲基)-3-苯基-丙酸合成路线 （共 4 条）
反应条件
jones' reagent in acetone
参考文献
Kim, Dong H.; Park, Jeong-il; Chung, Sang J.; Park, Jung Dae; Park, No-Kyung; Han, Jong Hoon
Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 8 p. 2553 - 2560
反应条件
in tetrahydrofuran 48 h; Ambient temperature;
参考文献
Fincham, Christopher I.; Higginbottom, Michael; Hill, David R.; Horwell, David C.; O'Toole, John C; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 8 p. 1472 - 1484
反应条件
1: 1.) diisopropyl amine, n-butyllithium / 1.) THF, hexane, 20 deg C, 15 min, 2.) THF, hexane, 5-15 deg C, 10 h 2: 86 percent / tetrahydrofuran / 48 h / Ambient temperature View Scheme
参考文献
Fincham, Christopher I.; Higginbottom, Michael; Hill, David R.; Horwell, David C.; O'Toole, John C; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 8 p. 1472 - 1484
反应条件
1: 90 percent / methanol; K2CO3; water / 2 h / 20 °C
2: 86 percent / acetyl chloride / 24 h / 20 °C
3: phosphate buffer; α-chymotrypsin; sodium hydroxide / 18 h / pH 7.5 / Enzymatic reaction
View Scheme
参考文献
Kim, Dong H.; Park, Jeong-il; Chung, Sang J.; Park, Jung Dae; Park, No-Kyung; Han, Jong Hoon
Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 8 p. 2553 - 2560
