5-氨基-1H-吡咯-2,4-二羧酸二乙酯合成路线 （共 5 条）
反应条件
1: 3-Amino-3-ethoxy-2-propensaeure-ethylester-hydrochlorid With sodium ethanolate in ethyl acetate 0.75 h; 2: 3-bromo-2-oxopropionic acid ethyl ester in ethyl acetate T=60°C; 0.333333 h;
参考文献
WO2006/14325 A2, ;
Page/Page column 59-60 ;
WO 2006/014325 A2
反应条件
N,N'-dimethyl-N,N'-propyleneurea in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethyl acetate
参考文献
US6140332 A1, ;
US 6140332 A
反应条件
in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethyl acetate
反应条件
1: T=140°C; 1 h; 2: With ammonia in methanol
参考文献
EXELIXIS, INC.
Patent: WO2006/14325 A2, 2006 ;
Location in patent: Page/Page column 59-60 ;
WO 2006/014325 A2
反应条件
formic acid; formamide in N,N-dimethyl-formamide
参考文献
Novartis AG
Patent: US6180636 B2, 2001 ;
