1: 2-(4-bromophenyl)acetic acid With thionyl chloride; N,N-dimethyl-formamide in toluene T=35 - 40°C; 2 h; Large scale reaction; 2: methylamine in water; toluene T=0 - 25°C; 19 h; Large scale reaction;
参考文献
Ulysse, Luckner G.; Yang, Qiang; McLaws, Mark D.; Keefe, Daniel K.; Guzzo, Peter R.; Haney, Brian P.
Organic Process Research and Development, 2010 , vol. 14, # 1 p. 225 - 228