1-BOC-4-哌啶甲酰肼合成路线 （共 11 条）
反应条件
hydrazine hydrate in ethanol 33 h; Reflux;
参考文献
BAYER SCHERING PHARMA AKTIENGESELLESCHAFT
Patent: US2011/144131 A1, 2011 ;
Location in patent: Page/Page column 29 ;
反应条件
1: in dichloromethane 2 h; 2: With hydrazine in dichloromethane T=20°C; 2 h;
参考文献
WO2006/36395 A2, ;
Page/Page column 51-52 ;
WO 2006/036395 A2
反应条件
1: With 1,1'-carbonyldiimidazole in dichloromethane T=20°C; 2 h; 2: With hydrazine in dichloromethane 2 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 11 p. 3178 - 3182
反应条件
hydrazine in dichloromethane T=20°C; 0.5 - 2 h; Product distribution / selectivity;
参考文献
WO2006/65601 A2, ;
Page/Page column 42; 44-45; 67-68 ;
WO 2006/065601 A2
反应条件
1: sodium hydrogencarbonate / tetrahydrofuran; water 2: hydrazine / methanol / Reflux View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 46, # 7 p. 3085 - 3092
反应条件
1: sodium hydrogencarbonate / tetrahydrofuran; water 2: hydrazine / methanol / Reflux View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 46, # 7 p. 3085 - 3092
反应条件
hydrazine in methanol Reflux;
参考文献
European Journal of Medicinal Chemistry, , vol. 46, # 7 p. 3085 - 3092
反应条件
1: |Reflux 2: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C View Scheme
反应条件
1.1: ethanol / 48 h / |Reflux 2.1: trifluoroacetic acid / dichloromethane / 1 h 2.2: pH 7 View Scheme
参考文献
WO2013/12723 A1, ;
WO 2013/012723 A1
反应条件
1: in tetrahydrofuran T=50°C; 4 h; 2: With toluene-4-sulfonic acid in toluene T=100°C; 18 h;
参考文献
US2005/154024 A1, ;
Page/Page column 22 ;
