(2E)-2-(2,3-二氢-6-甲氧基-1H-茚-1-亚基)乙腈合成路线 （共 11 条）
参考文献
Takeda Chemical Industries, Ltd.
Patent: US5922771 A1, 1999 ;
反应条件
1: cyanomethyl-phosphonic acid diethyl ester With sodium hydride in tetrahydrofuran T=20°C; 0.5 h; 2: 6-methoxy-1-oxo-indane in tetrahydrofuran T=20°C; Horner-Emmons olefination; 1 h;
参考文献
Fukatsu, Kohji; Uchikawa, Osamu; Kawada, Mitsuru; Yamano, Toru; Yamashita, Masayuki; Kato, Koki; Hirai, Keisuke; Hinuma, Shuji; Miyamoto, Masaomi; Ohkawa, Shigenori
Journal of Medicinal Chemistry, 2002 , vol. 45, # 19 p. 4212 - 4221
参考文献
Takeda Chemical Industries, Ltd.
Patent: US5922771 A1, 1999 ;
反应条件
ammonia; hydrogen; cobalt in ethanol T=40°C; P=3000.24 Torr; 6 h;
参考文献
Fukatsu, Kohji; Uchikawa, Osamu; Kawada, Mitsuru; Yamano, Toru; Yamashita, Masayuki; Kato, Koki; Hirai, Keisuke; Hinuma, Shuji; Miyamoto, Masaomi; Ohkawa, Shigenori
Journal of Medicinal Chemistry, 2002 , vol. 45, # 19 p. 4212 - 4221
反应条件
ammonia in methanol; ethanol; chloroform
参考文献
Takeda Chemical Industries, Ltd.
Patent: US5922771 A1, 1999 ;
反应条件
1: H2; ethanolic NH3 / Raney-Co 2: Et3N / tetrahydrofuran / 0 °C 3: H2; Ru(OAc)2[(S)-binap] / methanol / 70 °C / 68256.8 Torr View Scheme
参考文献
Fukatsu, Kohji; Uchikawa, Osamu; Kawada, Mitsuru; Yamano, Toru; Yamashita, Masayuki; Kato, Koki; Hirai, Keisuke; Hinuma, Shuji; Miyamoto, Masaomi; Ohkawa, Shigenori
Journal of Medicinal Chemistry, 2002 , vol. 45, # 19 p. 4212 - 4221
反应条件
1.1: H2; ethanolic NH3 / Raney-Co 2.1: Et3N / tetrahydrofuran / 0 °C 3.1: 86 percent / NaOAc; Br2 / 0 °C 4.1: 94 percent / BBr3 / CH2Cl2 / 0.67 h / -20 - 20 °C 5.1: NaH / dimethylformamide / 0 °C 5.2: 96 percent / dimethylformamide / 0 °C 6.1: 80 percent / various solvent(s) / 200 - 205 °C View Scheme
参考文献
Uchikawa, Osamu; Fukatsu, Kohji; Tokunoh, Ryosuke; Kawada, Mitsuru; Matsumoto, Kiyoharu; Imai, Yumi; Hinuma, Shuji; Kato, Koki; Nishikawa, Hisao; Hirai, Keisuke; Miyamoto, Masaomi; Ohkawa, Shigenori
Journal of Medicinal Chemistry, 2002 , vol. 45, # 19 p. 4222 - 4239
反应条件
ammonia; hydrogen; Raney-Nickel W2 in ethanol T=20°C; P=3000.24 Torr; 5 h;
参考文献
Fukatsu, Kohji; Uchikawa, Osamu; Kawada, Mitsuru; Yamano, Toru; Yamashita, Masayuki; Kato, Koki; Hirai, Keisuke; Hinuma, Shuji; Miyamoto, Masaomi; Ohkawa, Shigenori
Journal of Medicinal Chemistry, 2002 , vol. 45, # 19 p. 4212 - 4221
反应条件
1: H2; ethanolic NH3 / Raney-nickel / 40 °C / 3600.36 Torr 2: Et3N / tetrahydrofuran View Scheme
参考文献
Uchikawa, Osamu; Fukatsu, Kohji; Tokunoh, Ryosuke; Kawada, Mitsuru; Matsumoto, Kiyoharu; Imai, Yumi; Hinuma, Shuji; Kato, Koki; Nishikawa, Hisao; Hirai, Keisuke; Miyamoto, Masaomi; Ohkawa, Shigenori
Journal of Medicinal Chemistry, 2002 , vol. 45, # 19 p. 4222 - 4239
反应条件
1: H2; ethanolic NH3 / Raney-Co 2: Et3N / tetrahydrofuran / 0 °C View Scheme
参考文献
Fukatsu, Kohji; Uchikawa, Osamu; Kawada, Mitsuru; Yamano, Toru; Yamashita, Masayuki; Kato, Koki; Hirai, Keisuke; Hinuma, Shuji; Miyamoto, Masaomi; Ohkawa, Shigenori
Journal of Medicinal Chemistry, 2002 , vol. 45, # 19 p. 4212 - 4221
