3-氨基-5-(4-氯苯基)-2-噻吩甲酸合成路线 （共 6 条）
反应条件
1: With methanol; potassium hydroxide; water 2 h; Heating / reflux; 2: With sodium hydrogen sulphate in water
参考文献
WO2007/11284 A1, ;
Page/Page column 22-23 ;
WO 2007/011284 A1
反应条件
1: With potassium hydroxide in ethanol; water 4 h; Reflux; 2: With phosphoric acid in water
参考文献
Synthesis, , # 15 art. no. Z07410SS, p. 2543 - 2546
反应条件
1.1: trichlorophosphate / 0.25 h / 25 °C 1.2: 0.5 h / 20 - 60 °C 1.3: 0.5 h 2.1: sodium; methanol / 0.5 h / |Reflux 3.1: potassium hydroxide / methanol; water / 3 h / |Reflux View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 65, p. 223 - 231
反应条件
1: sodium; methanol / 0.5 h / |Reflux 2: potassium hydroxide / methanol; water / 3 h / |Reflux View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 65, p. 223 - 231
反应条件
thionyl chloride T=0°C; 24 h; Reflux;
参考文献
Hinsberger, Stefan; De Jong, Johannes C.; Groh, Matthias; Haupenthal, Joerg; Hartmann, Rolf W.
European Journal of Medicinal Chemistry, 2014 , vol. 76, p. 343 - 351
反应条件
in tetrahydrofuran; toluene
T=20°C; 2 h;
参考文献
Sahner, J. Henning; Groh, Matthias; Negri, Matthias; Haupenthal, Joerg; Hartmann, Rolf W.
European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 223 - 231
