1-(2-溴乙氧基)-2-硝基苯合成路线 （共 7 条）
反应条件
potassium carbonate in acetonitrile 3 h; Reflux;
参考文献
Dong, Xiaohu; Yang, Yiyao; Sun, Jian; Liu, Zhihong; Liu, Bi-Feng
Chemical Communications, 2009 , # 26 p. 3883 - 3885
参考文献
Journal fuer Praktische Chemie (Leipzig), , vol. <2> 24, p. 242
反应条件
potassium carbonate in acetone
参考文献
Baker; Lourens
Journal of medicinal chemistry, 1968 , vol. 11, # 1 p. 26 - 33
反应条件
1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C
2: ammonium chloride; iron / methanol; water / 2 h
View Scheme
参考文献
ARDELYX, INC.; LEWIS, Jason, G.; REICH, Nicholas; CHEN, Tao; JACOBS, Jeffrey W.; CHARMOT, Dominique; NAVRE, Marc; FINN, Patricia; CARRERAS, Christopher; SPENCER, Andrew
Patent: WO2013/96771 A1, 2013 ;
反应条件
1: 2-hydroxy-4-methylnitrobenzene With potassium carbonate in N,N-dimethyl-formamide
T=45°C; 0.5 h;
2: 1-(2-bromoethoxy)-2-nitrobenzene in N,N-dimethyl-formamide
T=130°C; 3 h;
参考文献
Dong, Xiaohu; Yang, Yiyao; Sun, Jian; Liu, Zhihong; Liu, Bi-Feng
Chemical Communications, 2009 , # 26 p. 3883 - 3885
反应条件
1: potassium carbonate
2: hydrogen / Pd/C
View Scheme
参考文献
Gee, Kyle R.; Archer, Eric A.; Lapham, Laura A.; Leonard, Mary E.; Zhou, Zhang-Lin; Bingham, John; Diwu, Zhenjun
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 14 p. 1515 - 1518
反应条件
hydrogenchloride; acetic acid; zinc(II) chloride
参考文献
Kulka; Van Stryk
Canadian Journal of Chemistry, 1955 , vol. 33, p. 1130,1135
