5-溴-2-碘吡啶-3-醇合成路线 （共 3 条）
反应条件
iodine; sodium carbonate in water T=20°C; 3.25 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2008/128961 A1, 2008 ;
Location in patent: Page/Page column 27; 75-76 ;
WO 2008/128961 A1
反应条件
1: N,N-dimethyl-formamide; methanol / 2 h / 80 °C / |Inert atmosphere; |Microwave irradiation 2: boron tribromide / dichloromethane / 48 h / -78 - 20 °C / |Inert atmosphere 3: sodium carbonate; iodine / water / 3 h / 20 °C / |Inert atmosphere View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 24 p. 6784 - 6788
反应条件
1: boron tribromide / dichloromethane / 48 h / -78 - 20 °C / |Inert atmosphere 2: sodium carbonate; iodine / water / 3 h / 20 °C / |Inert atmosphere View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 24 p. 6784 - 6788
