丁氧羰基-丙氨酸-D-谷氨酸-氨合成路线 （共 22 条）
反应条件
1: CF3COOH / 0.33 h / Ambient temperature 2: acetonitrile / 15 h / Ambient temperature 3: 85.4 percent / H2, AcOH / Pd black / methanol / 3 h / Ambient temperature View Scheme
参考文献
Phillips, Lawrence R.; Nishimura, Osamu; Fraser, Blair A.
Carbohydrate Research, 1984 , vol. 132, p. 275 - 286
反应条件
palladium on activated charcoal; hydrogen in methanol 18 h;
参考文献
Journal of the American Chemical Society, , vol. 127, # 7 p. 2056 - 2057
反应条件
1: D-iso-Gln-γ-OBn trifluoroacetate With triethylamine in N,N-dimethyl-formamide
T=20°C; 15 h;
2: 4-nitrophenyl N-Boc-L-alanine ester in N,N-dimethyl-formamide
T=20°C; 19 h;
参考文献
Fuda, Cosimo; Hesek, Dusan; Lee, Mijoon; Morio, Ken-Ichiro; Nowak, Thomas; Mobashery, Shahriar
Journal of the American Chemical Society, 2005 , vol. 127, # 7 p. 2056 - 2057
反应条件
in tetrahydrofuran
T=0 - 29°C; 29 h;
参考文献
Zhao, Nan; Ma, Yao; Liu, Gang
Chinese Chemical Letters, 2011 , vol. 22, # 12 p. 1443 - 1446
反应条件
N,N-dicyclohexylamine in N,N-dimethyl-formamide
2 h; Heating;
参考文献
Zaoral, Milan; Jezek, Jan; Krchnak, Viktor; Straka, Radovan
Collection of Czechoslovak Chemical Communications, 1980 , vol. 45, # 5 p. 1424 - 1446
反应条件
1: dicyclohexylcarbodiimide (DCC) / acetonitrile; dimethylformamide / 1.) 0 deg C, 1 h, 2.) RT, 4 h
2: acetonitrile / 15 h / Ambient temperature
View Scheme
参考文献
Kobayashi; Fukuda; Yukimasa; et al.
Bulletin of the Chemical Society of Japan, 1980 , vol. 53, # 9 p. 2570 - 2577
反应条件
1: CF3COOH / 0.25 h / Ambient temperature
2: acetonitrile / 15 h / Ambient temperature
View Scheme
参考文献
Kobayashi; Fukuda; Yukimasa; et al.
Bulletin of the Chemical Society of Japan, 1980 , vol. 53, # 9 p. 2570 - 2577
反应条件
1: 86.8 percent / dicyclohexylcarbodiimide (DCC) / ethyl acetate / 2 h / 0 °C
2: 70.8 percent / 25percent aq. ammonia / tetrahydrofuran / 2 h / Ambient temperature
3: CF3COOH / 0.25 h / Ambient temperature
4: acetonitrile / 15 h / Ambient temperature
View Scheme
参考文献
Kobayashi; Fukuda; Yukimasa; et al.
Bulletin of the Chemical Society of Japan, 1980 , vol. 53, # 9 p. 2570 - 2577
反应条件
1: 7.00 g / Et3N / H2O; dimethylformamide
2: 86.8 percent / dicyclohexylcarbodiimide (DCC) / ethyl acetate / 2 h / 0 °C
3: 70.8 percent / 25percent aq. ammonia / tetrahydrofuran / 2 h / Ambient temperature
4: CF3COOH / 0.25 h / Ambient temperature
5: acetonitrile / 15 h / Ambient temperature
View Scheme
参考文献
Kobayashi; Fukuda; Yukimasa; et al.
Bulletin of the Chemical Society of Japan, 1980 , vol. 53, # 9 p. 2570 - 2577
反应条件
1: 69 percent / triethylamine / dioxane / Ambient temperature
2: 59 percent / 3-<3-(dimethylamino)propyl>-1-ethylcarbodiimide (DAEC) / propan-2-ol / Ambient temperature
3: triethylamine / various solvent(s) / 1.) 24 h, 0 deg C, 2.) room temperature, 24 h
View Scheme
参考文献
Phillips, Lawrence R.; Nishimura, Osamu; Fraser, Blair A.
Carbohydrate Research, 1984 , vol. 132, p. 275 - 286
