丁氧羰基-丙氨酸-D-谷氨酸-氨合成路线 （共 22 条）
反应条件
1: 70.8 percent / 25percent aq. ammonia / tetrahydrofuran / 2 h / Ambient temperature
2: CF3COOH / 0.25 h / Ambient temperature
3: acetonitrile / 15 h / Ambient temperature
View Scheme
参考文献
Kobayashi; Fukuda; Yukimasa; et al.
Bulletin of the Chemical Society of Japan, 1980 , vol. 53, # 9 p. 2570 - 2577
反应条件
1: 58 percent / NaOH / dioxane; H2O
2: 78 percent / dicyclohexylamine / dimethylformamide / 2 h / Heating
View Scheme
参考文献
Zaoral, Milan; Jezek, Jan; Krchnak, Viktor; Straka, Radovan
Collection of Czechoslovak Chemical Communications, 1980 , vol. 45, # 5 p. 1424 - 1446
反应条件
1: 58 percent / NaOH / dioxane; H2O
2: 78 percent / dicyclohexylamine / dimethylformamide / 2 h / Heating
View Scheme
参考文献
Zaoral, Milan; Jezek, Jan; Krchnak, Viktor; Straka, Radovan
Collection of Czechoslovak Chemical Communications, 1980 , vol. 45, # 5 p. 1424 - 1446
反应条件
1: boron trifluoride diethyl etherate / 15 h / 20 °C
2: sodium hydrogencarbonate / 1,4-dioxane; water / 20 h / 20 °C
3: diisopropyl-carbodiimide / 25 h / 0 - 20 °C
4: ammonia / tetrahydrofuran / 1.5 h / -10 °C
5: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
6: tetrahydrofuran / 29 h / 0 - 29 °C
View Scheme
参考文献
Zhao, Nan; Ma, Yao; Liu, Gang
Chinese Chemical Letters, 2011 , vol. 22, # 12 p. 1443 - 1446
反应条件
1: ammonia / tetrahydrofuran / 1.5 h / -10 °C
2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
3: tetrahydrofuran / 29 h / 0 - 29 °C
View Scheme
参考文献
Zhao, Nan; Ma, Yao; Liu, Gang
Chinese Chemical Letters, 2011 , vol. 22, # 12 p. 1443 - 1446
反应条件
1: boron trifluoride diethyl etherate / 15 h / 20 °C
2: sodium hydrogencarbonate / 1,4-dioxane; water / 20 h / 20 °C
3: diisopropyl-carbodiimide / 25 h / 0 - 20 °C
4: ammonia / tetrahydrofuran / 1.5 h / -10 °C
5: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
6: tetrahydrofuran / 29 h / 0 - 29 °C
View Scheme
参考文献
Zhao, Nan; Ma, Yao; Liu, Gang
Chinese Chemical Letters, 2011 , vol. 22, # 12 p. 1443 - 1446
反应条件
triethylamine in acetonitrile
15 h; Ambient temperature; Yield given;
参考文献
Fukuda; Kobayashi; Yukimasa; Imada; Fujino; Azuma; Yamamura
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 8 p. 2215 - 2221
反应条件
1: 900 mg / NaHCO3 / acetonitrile; H2O
2: 83 percent / N-hydroxysuccinimide, DCC, 25 percent NH4OH / acetonitrile / 1 h
View Scheme
参考文献
Zemlyakov
Chemistry of Natural Compounds, 1998 , vol. 34, # 1 p. 78 - 79
反应条件
4-methyl-morpholine; isobutyl chloroformate
1.) DMF, 2.) DMF; Yield given. Multistep reaction;
参考文献
Hiebert, C. K.; Kopp, W. C.; Richerson, H. B.; Barfknecht, C. F.
Journal of Medicinal Chemistry, 1983 , vol. 26, # 12 p. 1729 - 1732
反应条件
(i) DCC, N-hydroxysuccinimide, THF, (ii) /BRN= 6319328/, Et3N; Multistep reaction;
参考文献
Kusumoto; Tarumi; Ikenaka; Shiba
Bulletin of the Chemical Society of Japan, 1976 , vol. 49, # 2 p. 533 - 539
