D-glucopyranose; glutamate dehydrogenase; [3H]-L-Alanine; ω-transaminase from Vibrio f luvialis; PLP; β-NADP+; lactate dehydrogenase in aq. phosphate buffer T=30°C; pH=7; 24 h; Enzymatic reaction; enantioselective reaction;

[3H]-L-Alanine; alanine dehydrogenase; formate dehydrogenase from Candida boidinii; ω-transaminase from variant Arthrobacter citreus; PLP; ammonium formate; β-NADP+ in aq. phosphate buffer T=30°C; pH=7; 24 h; Enzymatic reaction; enantioselective reaction;

hydrogenchloride in methanol T=25°C; 3 h;

1: NaBH4+tetrahydrofurfuryl alcohol / (S,S)-Co(II) complex catalyst (C46H50N2O4Co) / ethanol; CHCl3 / 4 h / 0 °C 2: HCl / methanol / 3 h / 25 °C View Scheme

sodium tetrahydroborate; borane-THF; 1-[([1,3,2]dioxaborolan-2-yloxy)-diphenyl-methyl]-2-methylpropylamine in 1,4-dioxane T=0°C; enantioselective reaction;

Yield given. Multistep reaction. Yields of byproduct given;