(S)-1-叔丁基 2-甲基 5-羟基吡咯烷-1,2-二羧酸合成路线 （共 15 条）
反应条件
1: 70 percent / SOCl2 / 2 h / 20 °C
2: 70 percent / DMAP / acetonitrile / 3 h
3: 86 percent / LiEt3BH / tetrahydrofuran / 2 h / -78 °C
View Scheme
参考文献
Aggarwal, Varinder K.; Astle, Christopher J.; Iding, Hans; Wirz, Beat; Rogers-Evans, Mark
Tetrahedron Letters, 2005 , vol. 46, # 6 p. 945 - 947
反应条件
dichloromethane; trimethylsilylazide; iodosylbenzene
T=-40°C; 15 h; various quantity of reagents, further L-proline derivatives; Product distribution;
参考文献
Magnus, Philip; Hulme, Christopher
Tetrahedron Letters, 1994 , vol. 35, # 44 p. 8097 - 8100
反应条件
1: methanol / 0 °C
2: 88.6 percent / 3,3-dimethyldioxirane / acetone; CH2Cl2 / 72 h / 25 °C
View Scheme
参考文献
Saladino, Raffaele; Mezzetti, Maurizio; Mincione, Enrico; Torrini, Ines; Paradisi, Mario Paglialunga; Mastropietro, Gaia
Journal of Organic Chemistry, 1999 , vol. 64, # 23 p. 8468 - 8474
反应条件
1: 90 percent / DMAP / CH2Cl2
2: 89 percent / DIBAL-H / CH2Cl2; tetrahydrofuran / -78 °C
View Scheme
参考文献
Clive, Derrick L. J.; Yeh, Vince S. C.
Tetrahedron Letters, 1998 , vol. 39, # 27 p. 4789 - 4792
反应条件
1: DMAP / CH2Cl2 / 18 h / 20 °C
2: 56 percent / BF3*OEt2 / CH2Cl2 / 0.17 h / -78 °C
3: TMSOTf; 2,6-lutidine / CH2Cl2 / 0 - 20 °C
View Scheme
参考文献
Shinada, Tetsuro; Hamada, Makoto; Kawasaki, Masanori; Ohfune, Yasufumi
Heterocycles, 2005 , vol. 66, # 1 p. 511 - 525
