1: 83 percent / KF*alumina / acetonitrile / 5 h / 50 °C 2: 93 percent / HCl / methanol; tetrahydrofuran / 7 h / Ambient temperature View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '113916', constants.ctx, '0')">N-bromosuccinmide</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '1696847', constants.ctx, '0')">dimethylsulfide</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1730800', constants.ctx, '0')">dichloromethane</a> <br />T=0&deg;C;&nbsp;3&nbsp;h;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 77 percent / NaN₃, Et₃N*HCl, NMP / 20 h / 120 &deg;C<br />2: 95 percent / pyridine / CH₂Cl₂ / 12 h / Ambient temperature<br />3: 85 percent / NBS, Me₂S / CH₂Cl₂ / 3 h / 0 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 95 percent / pyridine / CH₂Cl₂ / 12 h / Ambient temperature<br />2: 85 percent / NBS, Me₂S / CH₂Cl₂ / 3 h / 0 &deg;C<br /> <br /> &nbsp;