hydrogenchloride in tetrahydrofuran; methanol 7 h; Ambient temperature;

<b>Multi-step reaction with 4 steps<br /> </b>1: 77 percent / NaN₃, Et₃N*HCl, NMP / 20 h / 120 &deg;C<br />2: 95 percent / pyridine / CH₂Cl₂ / 12 h / Ambient temperature<br />3: 85 percent / NBS, Me₂S / CH₂Cl₂ / 3 h / 0 &deg;C<br />4: 83 percent / KF*alumina / acetonitrile / 5 h / 50 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 95 percent / pyridine / CH₂Cl₂ / 12 h / Ambient temperature<br />2: 85 percent / NBS, Me₂S / CH₂Cl₂ / 3 h / 0 &deg;C<br />3: 83 percent / KF*alumina / acetonitrile / 5 h / 50 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 85 percent / NBS, Me₂S / CH₂Cl₂ / 3 h / 0 &deg;C<br />2: 83 percent / KF*alumina / acetonitrile / 5 h / 50 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 72 percent / NaOH / methanol; acetonitrile<br />2: 83 percent / KF*alumina / acetonitrile / 5 h / 50 &deg;C<br /> <br /> &nbsp;