188290-36-0合成路线 （共 917 条）
反应条件
sulfuric acid; acetic acid
参考文献
Peter
Chemische Berichte, 1884 , vol. 17, p. 1345
反应条件
hydrogenchloride; zinc(II) chloride
参考文献
Gol'dfarb; Danjuschewskii
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1956 , p. 1361,1368; engl. Ausg. S. 1395, 1401
参考文献
Loefgren; Tegner
Acta Chemica Scandinavica (1947-1973), 1952 , vol. 6, p. 1020,1022
反应条件
n-butyllithium; N-fluoro-N-(phenylsulfonyl)benzene-sulfonamide in tetrahydrofuran; diethyl ether T=-70 - 0°C; 1 h;
参考文献
H. LUNDBECK A/S
Patent: WO2004/58739 A1, 2004 ;
Location in patent: Page 45; 57 ;
反应条件
pyridine; fluorine in chloroform T=-63°C; Yield given. Yields of byproduct given;
参考文献
Crestoni, Maria Elisa; Fornarini, Simonetta
Gazzetta Chimica Italiana, 1989 , vol. 119, # 3 p. 203 - 204
反应条件
fluorine in chloroform T=-63°C; other five-membered heteroaromatic compounds, other reagents; var. solvents; Product distributionMechanism;
参考文献
Cerichelli, Giorgio; Crestoni, Maria Elisa; Fornarini, Simonetta
Gazzetta Chimica Italiana, 1990 , vol. 120, p. 749 - 755
反应条件
1: With mercury(II) trifluoroacetate in benzene T=0°C; 0.0833333 h; 2: With triethylamine; palladium dichloride in benzene T=0°C; 0.166667 h; Further stages.;
参考文献
Buzhansky, Ludmila; Feit, Ben-Ami
Journal of Organic Chemistry, 2002 , vol. 67, # 21 p. 7523 - 7525
反应条件
1: With mercury(II) trifluoroacetate in benzene T=0°C; 0.25 h; 2: With triethylamine; palladium dichloride in benzene T=0°C; 0.25 h; Further stages.;
参考文献
Buzhansky, Ludmila; Feit, Ben-Ami
Journal of Organic Chemistry, 2002 , vol. 67, # 21 p. 7523 - 7525
反应条件
1: thiophene With n-butyllithium in tetrahydrofuran; hexane T=0°C; 1 h; 2: With zinc(II) chloride in tetrahydrofuran; hexane T=0°C; 1 h; 3: 2,3,5-tribromothiophene With [Pd(en)Cl2] in tetrahydrofuran; hexane T=20°C; regioselective reaction;
参考文献
Amb, Chad M.; Rasmussen, Seth C.
European Journal of Organic Chemistry, 2008 , # 5 p. 801 - 804
反应条件
1: thiophene With n-butyllithium in diethyl ether; hexane T=0°C; 1 h; 2: With zinc(II) chloride in diethyl ether; hexane T=0°C; 1 h; 3: 2,3,5-tribromothiophene With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in diethyl ether; hexane T=20°C; regioselective reaction;
参考文献
Amb, Chad M.; Rasmussen, Seth C.
European Journal of Organic Chemistry, 2008 , # 5 p. 801 - 804
