188290-36-0合成路线 （共 917 条）
反应条件
1: thiophene With n-butyllithium in tetrahydrofuran; hexane T=-78 - 20°C; 1.25 h; 2: CH3SO2Bt in tetrahydrofuran; hexane T=-78 - 20°C;
参考文献
Katritzky, Alan R.; Abdel-Fattah, Ashraf A. A.; Vakulenko, Anatoliy V.; Tao, Hui
Journal of Organic Chemistry, 2005 , vol. 70, # 23 p. 9191 - 9197
参考文献
Kuehnhanss et al.
Journal fuer Praktische Chemie (Leipzig), 1956 , vol. <4> 3, p. 137,142
反应条件
1: thiophene With n-butyllithium in tetrahydrofuran; hexane T=-5 - 0°C; Metallation; 1.5 h; 2: dimethyl-disulfide in tetrahydrofuran; hexane T=-10°C; Substitution; 1 h;
参考文献
Holland, Herbert L.; Turner, Carl D.; Andreana, Peter R.; Nguyen, Doan
Canadian Journal of Chemistry, 1999 , vol. 77, # 4 p. 463 - 471
反应条件
K10 montmorillonite; zinc(II) chloride in chlorobenzene T=80°C; thiomethylation; Further byproducts given;
参考文献
Clark, Peter D.; Mesher, Shaun T. E.; Primak, Alex
Phosphorus, Sulfur and Silicon and Related Elements, 1996 , vol. 114, # 1-4 p. 99 - 108
反应条件
n-butyllithium; diethyl ether anschliessend mit Schwefel und mit Methyljodid behandeln;
参考文献
Gol'dfarb et al.
Zhurnal Obshchei Khimii, 1959 , vol. 29, p. 2034,2041; engl. Ausg. S. 2003, 2009
反应条件
n-butyllithium; potassium tert-butylate 1.) THF and hexane; Yield given. Multistep reaction;
参考文献
Verkruijsse, H. D.; Brandsma, L.
Journal of Organometallic Chemistry, 1987 , vol. 332, p. 95 - 98
反应条件
n-butyllithium Yield given. Multistep reaction;
参考文献
Verkruijsse, H. D.; Brandsma, L.
Journal of Organometallic Chemistry, 1987 , vol. 332, p. 95 - 98
反应条件
aluminium trichloride; tetrachloroethane, 1,1,2,2-
参考文献
Meng, Qinghua; Sun, Yanhui; Ratovelomanana-Vidal, Virginie; Genet, Jean Pierre; Zhang, Zhaoguo
Journal of Organic Chemistry, 2008 , vol. 73, # 10 p. 3842 - 3847
反应条件
aluminium trichloride; Petroleum ether
参考文献
Steinkopf; Wolfram
Justus Liebigs Annalen der Chemie, 1924 , vol. 437, p. 25,31, 32
反应条件
1: N,N-dimethyl-2-propenamide With trifluoromethylsulfonic anhydride in anhydrous dichloroethane T=0°C; 0.416667 h; 2: thiophene in anhydrous dichloroethane 7 h; Heating / reflux;
参考文献
MEDIVIR AB
Patent: WO2006/84688 A1, 2006 ;
Location in patent: Page/Page column 74-75 ;
WO 2006/084688 A1
