188290-36-0合成路线 （共 917 条）
反应条件
trifluoromethylsulfonic anhydride in 1,2-dichloro-ethane 15 h; Heating / reflux;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1559422 A1, 2005 ;
Location in patent: Page/Page column 81 ;
EP 1559422 A1
反应条件
trifluoromethanesulfonic acid anhydride in 1,2-dichloro-ethane 8 h; Heating;
参考文献
Tetrahedron Letters, , vol. 37, # 24 p. 4199 - 4202
反应条件
potassium carbonate 1.) C2H4Cl2, reflux, 3 h, 2.) C2H4Cl2, Et2O, 1 h; Yield given. Multistep reaction;
参考文献
Baraznenok, Ivan L.; Nenajdenko, Valentine G.; Balenkova, Elizabeth S.
Synthesis, 1997 , # 4 p. 465 - 468
反应条件
tin(IV) chloride in dichloromethane T=0°C; 0.666667 h;
参考文献
Ishibashi, Hiroyuki; Takamuro, Iwao; Mizukami, Yo-ichi; Irie, Maki; Ikeda, Masazumi
Synthetic Communications, 1989 , vol. 19, # 3and4 p. 443 - 452
反应条件
1: thiophene With n-butyllithium; magnesium bromide in tetrahydrofuran T=20°C; 2 h; 2: 2-bromo-pyridine With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in tetrahydrofuran 18 h; Heating;
参考文献
Bayh, Omar; Awad, Hacan; Mongin, Florence; Hoarau, Christophe; Trecourt, Francois; Queguiner, Guy; Marsais, Francis; Blanco, Fernando; Abarca, Belen; Ballesteros, Rafael
Tetrahedron, 2005 , vol. 61, # 20 p. 4779 - 4784
反应条件
1: thiophene With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; ZnCl2*TMEDA in tetrahydrofuran; hexane T=0 - 20°C; Inert atmosphere; 2: alpha-chloropyridine With 1,1'-bis-(diphenylphosphino)ferrocene; palladium dichloride in tetrahydrofuran; hexane 24 h; RefluxInert atmosphere;
参考文献
Chemistry - A European Journal, , vol. 16, # 27 p. 8191 - 8201
反应条件
n-butyllithium in diethyl ether; hexane 0.5 h; Heating;
参考文献
Kauffmann, Thomas; Mitschker, Alfred; Woltermann, Annegret
Chemische Berichte, 1983 , vol. 116, # 3 p. 992 - 1000
反应条件
potassium carbonate in dichloromethane 10 h; Ambient temperatureIrradiation; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Seki, Koh-ichi; Ohkura, Kazue; Terashima, Masanao; Kanaoka, Yuichi
Heterocycles, 1984 , vol. 22, # 10 p. 2347 - 2350
反应条件
potassium carbonate in dichloromethane 10 h; Ambient temperatureIrradiation; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Seki, Koh-ichi; Ohkura, Kazue; Terashima, Masanao; Kanaoka, Yuichi
Heterocycles, 1984 , vol. 22, # 10 p. 2347 - 2350
反应条件
in dichloromethane Irradiation;
参考文献
Seki, Koh-ichi; Ohkura, Kazue; Terashima, Masanao; Kanaoka, Yuichi
Heterocycles, 1986 , vol. 24, # 1 p. 282
