188290-36-0合成路线 （共 917 条）
反应条件
hydrogenchloride; sodium hydroxide; sodium nitrite
参考文献
Buu-Hoi; Hoan
Recueil des Travaux Chimiques des Pays-Bas, 1950 , vol. 69, p. 1455,1466
反应条件
potassium tert-butylate in dimethyl sulfoxide
T=20°C; 3 h; Schlenk techniqueInert atmosphereIrradiation; TimeTemperatureConcentrationReagent/catalyst; Overall yield = 90 percent;
参考文献
Buden, Maria E.; Guastavino, Javier F.; Rossi, Roberto A.
Organic Letters, 2013 , vol. 15, # 6 p. 1174 - 1177
反应条件
dichloro bis(acetonitrile) palladium(II); lithium carbonate in 1,4-dioxane
T=140°C; 40 h; Schlenk technique; regioselective reaction;
参考文献
Yuan, Kedong; Doucet, Henri
Chemical Science, 2013 , vol. 5, # 1 p. 392 - 396
反应条件
in water; acetonitrile
Photolysis; Product distribution; Further Variations:Solvents;
参考文献
Manet, Ilse; Monti, Sandra; Grabner, Gottfried; Protti, Stefano; Dondi, Daniele; Dichiarante, Valentina; Fagnoni, Maurizio; Albini, Angelo
Chemistry - A European Journal, 2008 , vol. 14, # 3 p. 1029 - 1039
反应条件
in water; acetonitrile
Photolysis; Product distribution; Further Variations:Solvents;
参考文献
Manet, Ilse; Monti, Sandra; Grabner, Gottfried; Protti, Stefano; Dondi, Daniele; Dichiarante, Valentina; Fagnoni, Maurizio; Albini, Angelo
Chemistry - A European Journal, 2008 , vol. 14, # 3 p. 1029 - 1039
反应条件
1: thiophene With n-butyllithium in diethyl ether
T=-40°C; 0.5 h;
2: 2-pyrimidinyl chloride in diethyl ether
T=-40°C; 1 h;
3: With 2,3-dicyano-5,6-dichloro-p-benzoquinone in tetrahydrofuran
T=20°C; 0.416667 h; Further stages.;
参考文献
Bello, Angelica M.; Bende, Tanushree; Wei, Lianhu; Wang, Xiaoyang; Majchrzak-Kita, Beata; Fish, Eleanor N.; Kotra, Lakshmi P.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 9 p. 2734 - 2743
反应条件
1: thiophene With n-butyllithium in tetrahydrofuran
T=-15°C; 1 h; Inert atmosphere;
2: With zinc(II) chloride−TMEDA in tetrahydrofuran
T=-15 - 20°C;
3: 2,4-Dichloro-pyrimidine regioselective reactionFurther stages;
参考文献
Seggio, Anne; Priem, Ghislaine; Chevallier, Floris; Mongin, Florence
Synthesis, 2009 , # 21 p. 3617 - 3632
反应条件
n-butyllithium; 2,3-dicyano-5,6-dichloro-p-benzoquinone
1.) ether, -40 deg C, 15 min; -10 deg C, 30 min, 2.) THF, 25 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Strekowski, Lucjan; Mokrosz, Jerzy L.; Tanious, Farial A.; Watson, Rebecca A.; Harden, Donald; et al.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 6 p. 1231 - 1240
反应条件
1: thiophene With n-butyllithium in tetrahydrofuran; hexanes
T=-70 - 23°C; 0.75 h;
2: 6,13-pentacenequinone in tetrahydrofuran; hexanes
T=-23 - 60°C;
3: With hydrogenchloride; water; tin(ll) chloride in tetrahydrofuran; hexanes
T=60°C; 2 h;
参考文献
3M Innovative Properties Company
Patent: US2007/23748 A1, 2007 ;
Location in patent: Page/Page column 9 ;
参考文献
Demerseman et al.
Journal of the Chemical Society, 1954 , p. 4193,4196
