188290-36-0合成路线 （共 917 条）
反应条件
1: thiophene With n-butyllithium; N,N,N',N,-tetramethylethylenediamine in hexane
T=0°C; 0.916667 h; Reflux;
2: trimethylstannyl chloride in tetrahydrofuran; hexane
T=24°C; 15 h;
参考文献
Heinrich, Annika C. J.; Thiedemann, Birk; Gates, Paul J.; Staubitz, Anne
Organic Letters, 2013 , vol. 15, # 18 p. 4666 - 4669
反应条件
Yield given. Multistep reaction;
参考文献
Maryanoff, Bruce E.; McComsey, David F.; Duhl-Emswiler, Barbara A.
Journal of Organic Chemistry, 1983 , vol. 48, p. 5062 - 5074
反应条件
silver perchlorate; calcium carbonate in nitromethane
T=-15°C; 6 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Halazy, Serge; Hevesi, Laszlo
Journal of Organic Chemistry, 1983 , vol. 48, # 26 p. 5242 - 5246
反应条件
silver perchlorate; calcium carbonate in nitromethane
T=-15°C; 6 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Halazy, Serge; Hevesi, Laszlo
Journal of Organic Chemistry, 1983 , vol. 48, # 26 p. 5242 - 5246
反应条件
tin(IV) chloride in dichloromethane
T=0 - 20°C; 2.5 h;
参考文献
Goodman, M. M.; Kirsch, G.; Knapp, F. F.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 390 - 397
反应条件
n-butyllithium; diethyl ether
anschliessend mit Schwefel und mit Aethyljodid;
参考文献
Gol'dfarb et al.
Zhurnal Obshchei Khimii, 1959 , vol. 29, p. 2034,2041; engl. Ausg. S. 2003, 2009
反应条件
1: 3,5-bis(1,1-dimethylethyl)-4-hydroxybenzoylchloride With AlCl3, aluminium chloride in carbon disulfide
T=40°C; 0.5 h;
2: thiophene in carbon disulfide
参考文献
Pola Chemical Industries Inc.
Patent: EP1987811 A1, 2008 ;
Location in patent: Page/Page column 8 ;
反应条件
sulfuric acid
T=30 - 40°C;
参考文献
Terent'ew; Kadatskii
Zhurnal Obshchei Khimii, 1952 , vol. 22, p. 153,155; engl. Ausg. S. 189, 191
反应条件
anschl. in Eiswasser;
参考文献
Toehl
Chemische Berichte, 1894 , vol. 27, p. 666
反应条件
aluminium trichloride in dichloromethane
T=-6°C; 0.5 h;
参考文献
Dragas, Dario; Tanojo, Hanafi; Brussee, Johannes; Junginger, Hans E.; Bodde, Harry E.
Archiv der Pharmazie, 1996 , vol. 329, # 10 p. 465 - 467
