188290-36-0合成路线 （共 917 条）
反应条件
(i) nBuLi, Et2O, (ii) /BRN= 605945/; Multistep reaction;
参考文献
Gronowitz,S.; Roee,J.
Acta Chemica Scandinavica (1947-1973), 1965 , vol. 19, p. 1741 - 1748
反应条件
aluminium trichloride in 1,2-dichloro-ethane
Ambient temperature;
参考文献
Tedjamulia, Marvin L.; Tominaga, Yoshinori; Castle, Raymond N.; Lee, Milton L.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1143 - 1148
反应条件
1: thiophene With n-butyllithium in tetrahydrofuran; hexane
T=0°C; Inert atmosphere;
2: 1-(4'-methylphenylsulfonyl)-2-phenylethyne in tetrahydrofuran; pentane
T=-78°C; 0.25 h; Inert atmosphere; regioselective reaction;
参考文献
Garcia Ruano, Jose Luis; Aleman, Jose; Marzo, Leyre; Alvarado, Cuauhtemoc; Tortosa, Mariola; Diaz-Tendero, Sergio; Fraile, Alberto
Chemistry - A European Journal, 2012 , vol. 18, # 27 p. 8414 - 8422
反应条件
1: thiophene With n-butyllithium in tetrahydrofuran; hexane
T=20°C; 1 h;
2: 1-(2-phenylethynyl)-1H-1,2,3-benzotriazole in tetrahydrofuran; hexane
T=-78 - 20°C; 12 h; Further stages.;
参考文献
Katritzky, Alan R.; Abdel-Fattah, Ashraf A. A.; Wang, Mingyi
Journal of Organic Chemistry, 2002 , vol. 67, # 21 p. 7526 - 7529
反应条件
1: thiophene With n-butyllithium in tetrahydrofuran
T=0°C; 0.5 h;
2: dodecyl bromide in tetrahydrofuran
96 h; Heating; Further stages.;
参考文献
Ellinger, Stefan; Kreyes, Andreas; Ziener, Ulrich; Hoffmann-Richter, Carola; Landfester, Katharina; Moeller, Martin
European Journal of Organic Chemistry, 2007 , # 34 p. 5686 - 5702
反应条件
1: thiophene With n-butyllithium in hexane
T=-78°C; 1 h;
2: n-dodecyl iodide in hexane
T=-78 - 20°C;
参考文献
Wilson, Paul; Lacey, David; Sharma, Sanjay; Worthington, Brenda
Molecular Crystals and Liquid Crystals Science and Technology Section A: Molecular Crystals and Liquid Crystals, 2001 , vol. 368, p. 279 - 292
反应条件
n-butyllithium; N,N,N',N,-tetramethylethylenediamine
1.) hexane, 62 deg C, 1 h, 2.) reflux, 0.5 h; Yield given. Multistep reaction;
参考文献
Potts, Kevin T.; Cipullo, Michael J.; Ralli, Philip; Theodoridis, George
Journal of Organic Chemistry, 1982 , vol. 47, # 16 p. 3027 - 3038
反应条件
air; K10 montmorillonite; zinc(II) chloride in chlorobenzene
T=150°C; thiomethylation; P=54817.7 Torr; 5 h;
参考文献
Clark, Peter D.; Mesher, Shaun T. E.; Primak, Alex
Phosphorus, Sulfur and Silicon and Related Elements, 1996 , vol. 114, # 1-4 p. 99 - 108
反应条件
nBu4NPF6; platinum in liquid sulphur dioxide
T=-15°C; Substitution; methylthiation; 3 h; Electrochemical reaction;
参考文献
Glass, Richard S.; Jouikov, Viatcheslav V.
Tetrahedron Letters, 1999 , vol. 40, # 35 p. 6357 - 6358
反应条件
K10 montmorillonite; zinc(II) chloride in chlorobenzene
T=80°C; thiomethylation; Further byproducts given;
参考文献
Clark, Peter D.; Mesher, Shaun T. E.; Primak, Alex
Phosphorus, Sulfur and Silicon and Related Elements, 1996 , vol. 114, # 1-4 p. 99 - 108
