188290-36-0合成路线 （共 917 条）
反应条件
in tert-butyl alcohol
10 h; Irradiation;
参考文献
Ohkura, Kazue; Seki, Koh-ichi; Terashima, Masanao; Kanaoka, Yuichi
Heterocycles, 1990 , vol. 30, # 2 p. 957 - 962
反应条件
zinc(II) chloride in acetonitrile
4 h; Heating / reflux;
参考文献
AMGEN, INC.
Patent: WO2006/66172 A1, 2006 ;
Location in patent: Page/Page column 60 ;
WO 2006/066172 A1
反应条件
n-butyllithium
1.) THF, -40 deg C, 1 h, 2.) THF, a) -78 deg C, 1 h, b) RT, 2 h; Yield given. Multistep reaction;
参考文献
Aboutayab; Caddick; Jenkins; Joshi; Khan
Tetrahedron, 1996 , vol. 52, # 34 p. 11329 - 11340
反应条件
palladium diacetate in 1,4-dioxane; acetic acid
T=100°C; 8 h;
参考文献
Fujiwara, Yuzo; Maruyama, Osamu; Yoshidomi, Michiaki; Taniguchi, Hiroshi
Journal of Organic Chemistry, 1981 , vol. 46, # 5 p. 851 - 855
反应条件
n-butyllithium
1) THF, hexane, reflux, 1 h, 2) a) -56 deg C, 2 h, b) r.t., 0.5 h, c) 50 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Kossmehl, Gerhard; Hoppe, Frank Dirk; Hirsch, Barbara
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1993 , vol. 48, # 6 p. 826 - 843
参考文献
Pines et al.
Journal of the American Chemical Society, 1951 , vol. 73, p. 5173
反应条件
1: bromobenzene With lithium in diethyl ether
Metallation; 1 h; Heating;
2: thiophene in diethyl ether
T=20°C; Metallation; 1.5 h;
3: 3-quinuclidinecarboxylic acid ethyl ester With hydrogenchloride in diethyl ether; water
T=-10 - 20°C; Addition; 1.5 h;
参考文献
Kaminka, M. E.; Tupikina, S. M.; Alekseeva, N. V.; Koikov, L. N.; Vorob'eva, V. Ya.; Yanina, A. D.; Mikhlina, E. E.
Pharmaceutical Chemistry Journal, 1998 , vol. 32, # 12 p. 671 - 674
Khimiko-Farmatsevticheskii Zhurnal, 1998 , vol. 32, # 12 p. 46 - 48
反应条件
1: bromobenzene With lithium in diethyl ether
Metallation; 1 h; Heating;
2: thiophene; phenyllithium T=25°C; Addition; 0.75 h;
3: 3-quinuclidinecarboxylic acid ethyl ester in diethyl ether
T=-10 - -5°C; Condensation; 0.5 h;
参考文献
Koikov, L. N.; Polikarpov, M. V.; Alekseeva, N. V.; Obydenova, T. A.; Turchin, K. F.; Filipenko, T. Ya.
Pharmaceutical Chemistry Journal, 1998 , vol. 32, # 10 p. 546 - 549
Khimiko-Farmatsevticheskii Zhurnal, 1998 , vol. 32, # 10 p. 34 - 37
反应条件
1: thiophene With n-butyllithium in tetrahydrofuran; hexane
T=-78°C;
2: 1-nonyl bromide in tetrahydrofuran; hexane
T=-78 - 20°C;
参考文献
Pu, Shouzhi; Zhu, Shengsheng; Rao, Yi; Liu, Gang; Wei, Huizhen
Journal of Molecular Structure, 2009 , vol. 921, # 1-3 p. 89 - 100
反应条件
1: thiophene With n-butyllithium in hexane
T=-78°C; 1 h;
2: 1-iodo-n-nonane in hexane
T=-78 - 20°C;
参考文献
Wilson, Paul; Lacey, David; Sharma, Sanjay; Worthington, Brenda
Molecular Crystals and Liquid Crystals Science and Technology Section A: Molecular Crystals and Liquid Crystals, 2001 , vol. 368, p. 279 - 292
