2-甲基-2-丙基[(2R)-1-羟基-4-戊烯-2-基]氨基甲酸酯合成路线 （共 5 条）
反应条件
1: Et3N, DMAP / CH2Cl2 / 9 h / Ambient temperature 2: 71 percent / NaBH4, MeOH / ethanol / 24 h / Ambient temperature View Scheme
参考文献
Matsunaga, Hirofumi; Ishizuka, Tadao; Kunieda, Takehisa
Tetrahedron, 1997 , vol. 53, # 4 p. 1275 - 1294
反应条件
1: Et3N, DMAP / CH2Cl2 / 9 h / Ambient temperature 2: 71 percent / NaBH4, MeOH / ethanol / 24 h / Ambient temperature View Scheme
参考文献
Matsunaga, Hirofumi; Ishizuka, Tadao; Kunieda, Takehisa
Tetrahedron, 1997 , vol. 53, # 4 p. 1275 - 1294
反应条件
1: hydrogenchloride / 70 °C 2: triethylamine / dichloromethane / 1 h / 20 °C 3: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere; Cooling with ice View Scheme
参考文献
PHENEX PHARMACEUTICALS AG; KINZEL, Olaf; STEENECK, Christoph; KLEYMANN, Gerald; ALBERS, Michael; HOFFMANN, Thomas; KREMOSER, Claus; PEROVIC-OTTSTADT, Sanja; SCHLUeTER, Thomas
Patent: WO2011/107248 A1, 2011 ;
WO 2011/107248 A1
反应条件
1: triethylamine / dichloromethane / 1 h / 20 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere; Cooling with ice View Scheme
参考文献
PHENEX PHARMACEUTICALS AG; KINZEL, Olaf; STEENECK, Christoph; KLEYMANN, Gerald; ALBERS, Michael; HOFFMANN, Thomas; KREMOSER, Claus; PEROVIC-OTTSTADT, Sanja; SCHLUeTER, Thomas
Patent: WO2011/107248 A1, 2011 ;
WO 2011/107248 A1
反应条件
dipyridinium dichromate in N,N-dimethyl-formamide 6 h; Ambient temperature;
参考文献
Tetrahedron, , vol. 53, # 4 p. 1275 - 1294
