1: 89 percent / Br2 / 1 h 2: 1.) KF / 1.) DMF, RT, 15 min, 2.) DMF, 60 deg C, 6 h View Scheme

potassium fluoride 1.) DMF, RT, 15 min, 2.) DMF, 60 deg C, 6 h; Yield given. Multistep reaction;

xylene

pig liver esterase; buffer solution pH 7 in dimethyl sulfoxide 24 h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;