3-(6-氯-5-氟嘧啶-4-基)-2-(2,4-二氟苯基)-1-(1H-1,2,4-三唑-1-基)-2-丁醇盐酸盐合成路线 (共 2 条)
反应条件
1: With lead; iodine; zinc in tetrahydrofuran T=5 - 25°C; Reformatsky Reaction; Inert atmosphere; 2: With hydrogenchloride in isopropyl alcohol T=25°C;
参考文献
DONGKOOK PHARMACEUTICAL CO., LTD.; KWON, Hyuk Chul; RHO, Man Dong; CHA, Kyung Hoi
Patent: WO2011/96697 A2, 2011 ;
Location in patent: Page/Page column 15-16 ;
反应条件
1: With lead; iodine; zinc in tetrahydrofuran
T=5 - 25°C; Reformatsky Reaction; Inert atmosphere;
2: With hydrogenchloride in isopropyl alcohol
T=25°C;
参考文献
DONGKOOK PHARMACEUTICAL CO., LTD.; KWON, Hyuk Chul; RHO, Man Dong; CHA, Kyung Hoi
Patent: WO2011/96697 A2, 2011 ;
Location in patent: Page/Page column 15-16 ;