(S)-(+)-4-甲基苯亚磺酰胺合成路线 （共 22 条）
反应条件
1: With lithium hexamethyldisilazane in toluene T=-78°C; 3 h; Inert atmosphere; 2: With ammonium chloride in water T=20°C; 2 h; Cooling with dry ice; optical yield given as percent eeenantioselective reaction;
参考文献
Zhu, Rui-Heng; Shi, Xiao-Xin
Tetrahedron Asymmetry, 2011 , vol. 22, # 4 p. 387 - 393
反应条件
lithium hexamethyldisilazane in tetrahydrofuran T=-78 - 20°C; Substitution; 1 h;
参考文献
Davis; Zhang; Andemichael; Fang; Fanelli
Journal of Organic Chemistry, 1999 , vol. 64, # 4 p. 1403 - 1406
反应条件
1.1: NaH / tetrahydrofuran / 0.25 h / 0 °C 1.2: 73 percent / tetrahydrofuran / 3 h / 20 °C 2.1: α-chymotrypsin (EC 3.4.21.21) from bovine pancreas; aq. BES buffer; KCl / dimethylformamide / 96 h / pH 7.2 3.1: 3.58 g / hydrazine hydrate / 3 h View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 348, # 10-11 p. 1183 - 1192
反应条件
lithium hexamethyldisilazane in tetrahydrofuran T=-78 - 5°C; Title compound not separated from byproducts;
参考文献
Journal of the American Chemical Society, , vol. 127, # 5 p. 1374 - 1375
反应条件
recombinant subtilisin E in water T=37°C; pH=8.0; 24 h; Title compound not separated from byproducts;
参考文献
Journal of the American Chemical Society, , vol. 127, # 7 p. 2104 - 2113
反应条件
1: quinidine acetate / CH2Cl2 / 1 h / -78 °C 2: LiHMDS / tetrahydrofuran / -78 - 5 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 127, # 5 p. 1374 - 1375
反应条件
hydrazine hydrate T=20°C; 3 h;
参考文献
Journal of the American Chemical Society, , vol. 127, # 7 p. 2104 - 2113
反应条件
1: recombinant subtilisin E / H2O; various solvent(s) / 24 h / 37 °C / pH 8.0 2: hydrazine hydrate / 3 h / 20 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 127, # 7 p. 2104 - 2113
反应条件
1: With lithium hexamethyldisilazane in tetrahydrofuran T=-70°C; 2: With ammonium chloride in tetrahydrofuran; water
参考文献
European Journal of Organic Chemistry, , # 8 p. 1449 - 1458
反应条件
1.1: oxalyl chloride / toluene / 1 h / 20 °C 1.2: 86 percent / NH4OH / toluene; ethyl acetate / 1 h / 20 °C 2.1: NaH / tetrahydrofuran / 0.25 h / 0 °C 2.2: 73 percent / tetrahydrofuran / 3 h / 20 °C 3.1: α-chymotrypsin (EC 3.4.21.21) from bovine pancreas; aq. BES buffer; KCl / dimethylformamide / 96 h / pH 7.2 4.1: 3.58 g / hydrazine hydrate / 3 h View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 348, # 10-11 p. 1183 - 1192
