(S)-(+)-4-甲基苯亚磺酰胺合成路线 （共 22 条）
反应条件
1: α-chymotrypsin (EC 3.4.21.21) from bovine pancreas; aq. BES buffer; KCl / dimethylformamide / 96 h / pH 7.2 2: 3.58 g / hydrazine hydrate / 3 h View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 348, # 10-11 p. 1183 - 1192
反应条件
lithium hexamethyldisilazane Inert atmosphere;
参考文献
Hellal, Malik; Singh, Shambhavi; Cuny, Gregory D.
Tetrahedron, 2012 , vol. 68, # 6 p. 1674 - 1681
反应条件
ammonia; lithium; iron nitrate (III) in tetrahydrofuran T=-78°C; 0.75 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Journal of Organic Chemistry, , vol. 77, # 1 p. 690 - 695
反应条件
in tetrahydrofuran T=-78 - 20°C; 5 h; Yield given. Yields of byproduct given;
参考文献
Journal of Organic Chemistry, , vol. 62, # 8 p. 2555 - 2563
反应条件
hydrazine hydrate 3 h;
参考文献
Savile, Christopher K.; Kazlauskas, Romas J.
Advanced Synthesis and Catalysis, 2006 , vol. 348, # 10-11 p. 1183 - 1192
反应条件
water; ammonium chloride T=20°C; 1 h;
参考文献
Worch, Christin; Atodiresei, Iuliana; Raabe, Gerhard; Bolm, Carsten
Chemistry - A European Journal, 2010 , vol. 16, # 2 p. 677 - 683
反应条件
1.1: boron trifluoride diethyl etherate / methanol; toluene / 155 h / -5 °C 2.1: lithium hexamethyldisilazane / toluene / 3 h / -78 °C / Inert atmosphere 2.2: 2 h / 20 °C / Cooling with dry ice View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 22, # 4 p. 387 - 393
反应条件
1: tetrahydrofuran / 0.5 h / -70 °C / Inert atmosphere 2: ammonia; lithium; iron nitrate (III) / tetrahydrofuran / 0.75 h / -78 °C / Inert atmosphere View Scheme
参考文献
Journal of Organic Chemistry, , vol. 77, # 1 p. 690 - 695
反应条件
titanium tetraethoxide T=70°C; 1 h; Neat (no solvent)Microwave irradiationInert atmosphere;
参考文献
Collados, Juan F.; Toledano, Estefania; Guijarro, David; Yus, Miguel
Journal of Organic Chemistry, 2012 , vol. 77, # 13 p. 5744 - 5750
反应条件
1: 92 percent / DEAD / tetrahydrofuran / 0.67 h / 0 - 25 °C 2: benzene / 1.5 h / 40 °C 3: tetrahydrofuran / 0.25 h / -70 °C 4: 80 percent / TFA / CH2Cl2 / 1 h / 0 - 25 °C View Scheme
参考文献
Asensio, Amparo; Bravo, Pierfrancesco; Crucianelli, Marcello; Farina, Alessandra; Fustero, Santos; Soler, Juan Garcia; Meille, Stefano V.; Panzeri, Walter; Viani, Fiorenza; Volonterio, Alessandro; Zanda, Matteo
European Journal of Organic Chemistry, 2001 , # 8 p. 1449 - 1458
