反应条件
1: pyridine / N,N-dimethyl-formamide
2: potassium carbonate; urea hydrogen peroxide addition compound / acetone; water
3: hydrogen bromide / water
4: triphenylphosphine; carbon tetrabromide / dichloromethane / 22 h / 0 - 20 °C
5: sodium azide / acetone; water / 0.33 h / 70 °C / |Microwave irradiation
6: triphenylphosphine / water; tetrahydrofuran / 19 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
Lindgren, Anders E.G.; Karlberg, Tobias; Ekblad, Torun; Spjut, Sara; Thorsell, Ann-Gerd; Andersson, C. David; Nhan, Ton Tong; Hellsten, Victor; Weigelt, Johan; Linusson, Anna; Schueler, Herwig; Elofsson, Mikael
Journal of Medicinal Chemistry, 2013 , vol. 56, # 23 p. 9556 - 9568