(6R)-3-{1-[3-(二苄基氨基)苯基]丙基}-4-羟基-6-(2-苯基乙基)-6-(1-丙炔-1-基)-5,6-二氢-2H-吡喃-2-酮合成路线 （共 6 条）
反应条件
potassium tert-butylate in tetrahydrofuran T=0°C;
参考文献
Judge; Phillips; Morris; Lovasz; Romines; Luke; Tulinsky; Tustin; Chrusciel; Dolak; Mizsak; Watt; Vander Velde; Strohbach; Gammill
Journal of the American Chemical Society, 1997 , vol. 119, # 15 p. 3627 - 3628
反应条件
1: 95 percent / n-BuLi / tetrahydrofuran / -78 °C 2: CuBr, DMS / tetrahydrofuran / 1 h / 0 °C 3: 1.) H3O+, 2.) Na2CO3 / 2.) H2O, CH2Cl2 6: 67 percent / t-BuOK / tetrahydrofuran / 0 °C View Scheme
参考文献
Judge; Phillips; Morris; Lovasz; Romines; Luke; Tulinsky; Tustin; Chrusciel; Dolak; Mizsak; Watt; Vander Velde; Strohbach; Gammill
Journal of the American Chemical Society, 1997 , vol. 119, # 15 p. 3627 - 3628
反应条件
3: 67 percent / t-BuOK / tetrahydrofuran / 0 °C View Scheme
参考文献
Judge; Phillips; Morris; Lovasz; Romines; Luke; Tulinsky; Tustin; Chrusciel; Dolak; Mizsak; Watt; Vander Velde; Strohbach; Gammill
Journal of the American Chemical Society, 1997 , vol. 119, # 15 p. 3627 - 3628
反应条件
2: 67 percent / t-BuOK / tetrahydrofuran / 0 °C View Scheme
参考文献
Judge; Phillips; Morris; Lovasz; Romines; Luke; Tulinsky; Tustin; Chrusciel; Dolak; Mizsak; Watt; Vander Velde; Strohbach; Gammill
Journal of the American Chemical Society, 1997 , vol. 119, # 15 p. 3627 - 3628
反应条件
1: CuBr, DMS / tetrahydrofuran / 1 h / 0 °C 2: 1.) H3O+, 2.) Na2CO3 / 2.) H2O, CH2Cl2 5: 67 percent / t-BuOK / tetrahydrofuran / 0 °C View Scheme
参考文献
Judge; Phillips; Morris; Lovasz; Romines; Luke; Tulinsky; Tustin; Chrusciel; Dolak; Mizsak; Watt; Vander Velde; Strohbach; Gammill
Journal of the American Chemical Society, 1997 , vol. 119, # 15 p. 3627 - 3628
反应条件
1: H2 / Pd/C / methanol; ethyl acetate 2: 81 percent / pyridine / CH2Cl2 View Scheme
参考文献
Journal of the American Chemical Society, , vol. 119, # 15 p. 3627 - 3628
