7-羟基-3,4-二氢异喹啉-2(1h)-羧酸叔丁酯合成路线 （共 11 条）
反应条件
triethylamine in tetrahydrofuran; water T=20°C; 16 h;
参考文献
Middleton, Donald S.; Maw, Graham N.; Challenger, Clare; Jessiman, Alan; Johnson, Patrick S.; Million, William A.; Nichols, Carly L.; Price, Jenny A.; Trevethick, Michael
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 4 p. 905 - 910
反应条件
triethylamine in dichloromethane 1 h; Cooling with ice;
参考文献
Ajinomoto Co., Inc.
Patent: EP2311810 A1, 2011 ;
Location in patent: Page/Page column 20 ;
反应条件
triethylamine in dichloromethane; ethyl acetate
参考文献
Akzo Nobel N.V.
Patent: US6194409 B1, 2001 ;
反应条件
1: H2; AcOH / PtO2 / 3 h / 2280 Torr 2: aq. HBr / 3 h / Heating 3: aq. NaOH / dioxane / 12 h / 20 °C View Scheme
参考文献
Ueno, Hiroshi; Yokota, Katsuyuki; Hoshi, Jun-Ichi; Yasue, Katsutaka; Hayashi, Mikio; Uchida, Itsuo; Aisaka, Kazuo; Hase, Yasunori; Katoh, Susumu; Cho, Hidetsura
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 1 p. 185 - 189
反应条件
1: 83 percent / H2, glacial AcOH / PtO2 / 48 h / Ambient temperature 2: 89 percent / Et3N / CH2Cl2 / 1 h / 5 °C View Scheme
参考文献
Ajinomoto Co., Inc.
Patent: EP2311810 A1, 2011 ;
反应条件
sodium hydroxide in 1,4-dioxane T=20°C;
参考文献
Ueno, Hiroshi; Yokota, Katsuyuki; Hoshi, Jun-Ichi; Yasue, Katsutaka; Hayashi, Mikio; Hase, Yasunori; Uchida, Itsuo; Aisaka, Kazuo; Katoh, Susumu; Cho, Hidetsura
Journal of Medicinal Chemistry, 2005 , vol. 48, # 10 p. 3586 - 3604
反应条件
1: toluene / 6 h / Heating 2: trifluoroacetic acid anhydride, BF3*Et2O / toluene / 120 h / Ambient temperature 3: 83 percent / H2, glacial AcOH / PtO2 / 48 h / Ambient temperature 4: 89 percent / Et3N / CH2Cl2 / 1 h / 5 °C View Scheme
参考文献
Kucznierz, Ralf; Grams, Frank; Leinert, Herbert; Marzenell, Klaus; Engh, Richard A.; Von der Saal, Wolfgang
Journal of Medicinal Chemistry, 1998 , vol. 41, # 25 p. 4983 - 4994
参考文献
Japan Tobacco Inc.
Patent: US6562828 B1, 2003 ;
US 6562828 B1
反应条件
1: aq. HBr / 3 h / Heating 2: aq. NaOH / dioxane / 12 h / 20 °C View Scheme
参考文献
Ueno, Hiroshi; Yokota, Katsuyuki; Hoshi, Jun-Ichi; Yasue, Katsutaka; Hayashi, Mikio; Uchida, Itsuo; Aisaka, Kazuo; Hase, Yasunori; Katoh, Susumu; Cho, Hidetsura
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 1 p. 185 - 189
反应条件
1: toluene / Heating 2: aq. H2SO4 / 0 °C 3: H2; AcOH / PtO2 / 20 °C / 2280 Torr 4: aq. HBr / Heating 5: aq. NaOH / dioxane / 20 °C View Scheme
参考文献
Ueno, Hiroshi; Yokota, Katsuyuki; Hoshi, Jun-Ichi; Yasue, Katsutaka; Hayashi, Mikio; Uchida, Itsuo; Aisaka, Kazuo; Hase, Yasunori; Katoh, Susumu; Cho, Hidetsura
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 1 p. 185 - 189
