N-(4-氯吡啶-2-基)-2,2-二甲基丙酰胺合成路线 （共 6 条）
反应条件
pyridine T=0 - 20°C; 12 h;
参考文献
CANCER RESEARCH TECHNOLOGY LIMITED
Patent: WO2009/44162 A1, 2009 ;
Location in patent: Page/Page column 218-219 ;
WO 2009/044162 A1
参考文献
The Regents of the University of Michigan
Patent: US6214801 B1, 2001 ;
反应条件
N-chloro-succinimide in acetonitrile 2 h; Heating;
参考文献
Gudmundsson, Kristjan S.; Hinkley, Jack M.; Brieger, Michael S.; Drach, John C.; Townsend, Leroy B.
Synthetic Communications, 1997 , vol. 27, # 5 p. 861 - 870
反应条件
1: 95 percent / N-chlorosuccinimide / acetonitrile / 2 h / Heating 2: 97 percent / HCl / 10 h / Heating View Scheme
参考文献
Gudmundsson, Kristjan S.; Hinkley, Jack M.; Brieger, Michael S.; Drach, John C.; Townsend, Leroy B.
Synthetic Communications, 1997 , vol. 27, # 5 p. 861 - 870
反应条件
1: 4-chloro-2-trimethylacetamidopyridine With n-butyllithium in tetrahydrofuran
T=-78°C;
2: N,N-dimethyl-formamide in tetrahydrofuran
T=-78°C;
参考文献
MERCK SERONO S.A.; XIAO, Yufang; CHEN, Xiaoling; KARRA, Srinivasa R.; HUCK, Bayard R.; SUTTON, Amanda E.; GOUTOPOULOS, Andreas
Patent: WO2010/2779 A2, 2010 ;
Location in patent: Page/Page column 56-57 ;
WO 2010/002779 A2
反应条件
1: N-chloro-succinimide / acetonitrile / 5 h / 100 °C
2: sulfuric acid; nitric acid / 1 h / 65 - 100 °C
View Scheme
参考文献
HANMI PHARM. CO., LTD.; LEE, Kyung Ik; SIM, Jae Yi; KIM, Ho Seok; HA, Tae Hee; SUH, Kwee Hyun
Patent: WO2013/100631 A1, 2013 ;
