1-Boc-4-甲氧基哌啶合成路线 （共 8 条）
反应条件
sodium hydride in DMF (N,N-dimethyl-formamide) 0.5 h;
参考文献
Castro Pineiro, Jose Luis; Dinnell, Kevin; Elliott, Jason Matthew; Hollingworth, Gregory John; Shaw, Duncan Edward; Swain, Christopher John
Patent: US2003/236250 A1, 2003 ;
Location in patent: Page 25 ;
反应条件
1: 1-(tert-Butyloxycarbonyl)-4-piperidinol With sodium hydride in DMF (N,N-dimethyl-formamide) 0.333333 h; 2: methyl iodide in DMF (N,N-dimethyl-formamide) 48 h;
参考文献
Kawahara, Tetsuya; Kotake, Makoto; Yoneda, Naoki; Hirota, Shinsuke; Ohkuro, Masayoshi
Patent: US2005/261291 A1, 2005 ;
Location in patent: Page/Page column 67 ;
反应条件
pyridine in tetrahydrofuran; methanol; water
参考文献
Akzo Nobel N.V.
Patent: US6194409 B1, 2001 ;
反应条件
1.1: ethanol; sodium tetrahydroborate / 0.5 h / 0 - 23 °C 2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C 2.2: 2 h / 0 - 23 °C View Scheme
参考文献
HETERO RESEARCH FOUNDATION; PANDURANGA ADULLA, Reddy; PARTHASARADHI REDDY, Bandi; MANOHAR SHARMA, Vedula; RATHNAKAR REDDY, Kura; PREM KUMAR, Mamnoor; BHASKAR REDDY, Kasireddy; NARSINGAM, Mogili; VENKATI, Mukkera; VL SUBRAHMANYAM, Lanka; MALLIKARJUN REDDY, Ravi
Patent: WO2013/160810 A2, 2013 ;
反应条件
1: triethylamine / dichloromethane / 20 °C 2: potassium hydroxide / dimethyl sulfoxide / 4 h / 25 °C View Scheme
参考文献
HETERO RESEARCH FOUNDATION; PANDURANGA ADULLA, Reddy; PARTHASARADHI REDDY, Bandi; MANOHAR SHARMA, Vedula; RATHNAKAR REDDY, Kura; PREM KUMAR, Mamnoor; BHASKAR REDDY, Kasireddy; NARSINGAM, Mogili; VENKATI, Mukkera; VL SUBRAHMANYAM, Lanka; MALLIKARJUN REDDY, Ravi
Patent: WO2013/160810 A2, 2013 ;
反应条件
1: triethylamine / dichloromethane / 20 °C 2: potassium hydroxide / dimethyl sulfoxide / 4 h / 25 °C View Scheme
参考文献
GLAXOSMITHKLINE LLC; QIN, Donghui; CHRISTENSEN, Sieg; WU, Chengde; ZHANG, Zhiliu; YU, Haiyu; YUAN, Jiangxing
Patent: WO2013/149362 A1, 2013 ;
反应条件
hydrogenchloride in 1,4-dioxane T=0 - 23°C; 2 h;
参考文献
H. LUNDBECK A/S
Patent: US2011/92475 A1, 2011 ;
Location in patent: Page/Page column 18 ;
参考文献
HOKURIKU SEIYAKU CO., LTD.
Patent: EP1130016 A1, 2001 ;
