2-氨基-N-(2,6-二甲基苯基)乙酰胺合成路线 （共 11 条）
反应条件
hydrogen; 10 palladium on activated carbon in ethanol
参考文献
CORUS PHARMA
Patent: WO2005/25498 A2, 2005 ;
Location in patent: Page/Page column 49 ;
反应条件
1.1: 4-methyl-morpholine; isobutyl chloroformate / N,N-dimethyl-formamide / 0.17 h / -20 °C 1.2: 4 h / 20 °C 2.1: trifluoroacetic acid / 0.5 h / 20 °C View Scheme
参考文献
Medicinal Chemistry Research, , vol. 22, # 10 p. 4708 - 4714
反应条件
trifluoroacetic acid T=20°C; 0.5 h;
参考文献
Medicinal Chemistry Research, , vol. 22, # 10 p. 4708 - 4714
反应条件
Vitamin C; Agrocybe aegerita peroxygenase; dihydrogen peroxide T=20°C; pH=7; 0.05 h; aq. phosphate bufferEnzymatic reaction; regioselective reaction;
参考文献
Biochemical Pharmacology, , vol. 82, # 7 p. 789 - 796
反应条件
ammonia Multistep reaction;
参考文献
Pharmazie, , vol. 35, # 5-6 p. 278 - 284
反应条件
(i) DCC, CH2Cl2, (ii) H2, Pd-C, EtOH; Multistep reaction;
参考文献
Journal of Pharmaceutical Sciences, , vol. 66, # 8 p. 1180 - 1190
反应条件
T=37°C; in vitro methabolism; Vmax (maximal velocity of metabolism) and Km (Michaelis constant) for ring hydroxylation and N-deethylation in microsomal incubation mixture (pH 7.4);
参考文献
Journal of Pharmaceutical Sciences, , vol. 74, # 11 p. 1219 - 1224
反应条件
T=37°C; in vitro methabolism; Vmax (maximal velocity of metabolism) and Km (Michaelis constant) for ring hydroxylation and N-deethylation in microsomal incubation mixture (pH 7.4);
参考文献
Journal of Pharmaceutical Sciences, , vol. 74, # 11 p. 1219 - 1224
反应条件
1: K2CO3 / methanol; H2O / 3 h / 25 °C 2: H2 / 10percent Pd/C / CHCl3 / 25 °C / 760 Torr 3: 55 percent / EDTA-Na2, Na2WO4*2HCl, aq. H2O2 / methanol / 72 h / 20 °C View Scheme
参考文献
Hankovszky; Hideg; Bodi; Frank
Journal of Medicinal Chemistry, 1986 , vol. 29, # 7 p. 1138 - 1152
反应条件
in chloroform 2 h; Heating;
参考文献
Hankovszky; Hideg; Bodi; Frank
Journal of Medicinal Chemistry, 1986 , vol. 29, # 7 p. 1138 - 1152
