(R)-1-(4-苄氧基-3-硝基苯基)-2-溴乙醇合成路线 （共 17 条）
反应条件
1.1: potassium carbonate / water; acetone / 20 °C 1.2: 17 h / Reflux 2.1: bromine / acetic acid / 20 °C 3.1: [{(η5-C5Me5)RhCl}2(μ-Cl)2]; sodium formate / water / 2 h / 20 - 40 °C / Inert atmosphere View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 4 p. 1523 - 1526
反应条件
1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C 1.2: 3 h / 20 °C / Reflux 2.1: tetra-n-butylammonium tribromide / tetrahydrofuran; methanol / 4 h 3.1: BH3*N,N-diethylanilline; (1R,2S)-1-amino-2,3-dihydro-1H-inden-2-ol / tetrahydrofuran / 3.5 h / 3 - 5 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 15, # 6 p. 1247 - 1255
反应条件
sodium hydroxide in methanol 0.5 h;
参考文献
Hett, Robert; Fang, Qun Kevin; Gao, Yun; Hong, Yaping; Butler, Hal T.; Nie, Xiaoyi; Wald, Stephen A.
Tetrahedron Letters, 1997 , vol. 38, # 7 p. 1125 - 1128
反应条件
potassium carbonate in methanol T=20°C; Cyclization; 2.5 h; Title compound not separated from byproducts;
参考文献
Campos, Francisco; Bosch, M. Pilar; Guerrero, Angel
Tetrahedron Asymmetry, 2000 , vol. 11, # 13 p. 2705 - 2717
反应条件
1: (R)-2-bromo-1-[3-nitro-4-(benzyloxy)phenyl]ethanol With hydrogen; platinum(IV) oxide in tetrahydrofuran; toluene T=20°C; P=2844.39 Torr; 14 h; 2: formic acid in tetrahydrofuran; acetic anhydride; toluene T=20°C; 16 h;
参考文献
JOHNSON, Michael, Ross
Patent: WO2007/146867 A2, 2007 ;
Location in patent: Page/Page column 51-52 ;
WO 2007/146867 A2
反应条件
1: With dimethylsulfide; palladium 10 on activated carbon in tetrahydrofuran 0.5 h; Inert atmosphere; 2: With hydrogen in tetrahydrofuran T=20 - 40°C; P=3345.86 Torr; 3.5 h; chemoselective reaction;
参考文献
Wilkinson, H. Scott; Hett, Robert; Tanoury, Gerald J.; Senanayake, Chris H.; Wald, Stephen A.
Organic Process Research and Development, 2000 , vol. 4, # 6 p. 567 - 570
反应条件
1: hydrogen; platinum(IV) oxide / tetrahydrofuran; toluene / 20 °C / 2327.23 Torr 2: acetic anhydride / tetrahydrofuran; toluene / 2.5 h / 0 - 20 °C View Scheme
参考文献
Huang, Ling; Shan, Wenjun; Zhou, Qi; Xie, Jiaxing; Lai, Kefang; Li, Xingshu
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 1 p. 249 - 253
